Impact of anaemia on lung function and exercise capacity in patients with stable severe chronic obstructive pulmonary disease

OBJECTIVE: This study intended to search for potential correlations between anaemia in patients with severe chronic obstructive pulmonary disease (COPD; GOLD stage III) and pulmonary function at rest, exercise capacity as well as ventilatory efficiency, using pulmonary function test (PFT) and cardiopulmonary exercise testing (CPET). SETTING: The study was undertaken at Shanghai Pulmonary Hospital, a tertiary-level centre affiliated to Tongji University. It caters to a large population base within Shanghai and referrals from centres in other cities as well. PARTICIPANTS: 157 Chinese patients with stable severe COPD were divided into 2 groups: the anaemia group (haemoglobin (Hb) <12.0 g/dL for males, and <11 g/dL for females (n=48)) and the non-anaemia group (n=109). PRIMARY AND SECONDARY OUTCOME MEASURES: Arterial blood gas, PFT and CPET were tested in all patients. RESULTS: (1) Diffusing capacity for carbon monoxide (DLCO) corrected by Hb was significantly lower in the anaemia group ((15.3±1.9) mL/min/mm Hg) than in the non-anaemia group ((17.1±2.1) mL/min/mm Hg) (p<0.05). A significant difference did not exist in the level of forced expiratory volume in 1 s (FEV(1)), FEV(1)%pred, FEV(1)/forced vital capacity (FVC), inspiratory capacity (IC), residual volume (RV), total lung capacity (TLC) and RV/TLC (p>0.05). (2) Peak Load, Peak oxygen uptake ([Image: see text]), Peak [Image: see text]%pred, Peak [Image: see text], Peak [Image: see text] pulse and the ratio of [Image: see text] increase to WR increase ([Image: see text]) were significantly lower in the anaemia group (p<0.05); however, Peak minute ventilation (VE), Lowest [Image: see text]/carbon dioxide output ([Image: see text]) and Peak dead space/tidal volume ratio (VD/VT) were similar between the 2 groups (p>0.05). (3) A strong positive correlation was found between Hb concentration and Peak [Image: see text] in patients with anaemia (r=0.702, p<0.01). CONCLUSIONS: Anaemia has a negative impact on gas exchange and exercise tolerance during exercise in patients with severe COPD. The decrease in amplitude of Hb levels is related to the quantity of oxygen uptake.