Stevens–Johnson syndrome induced by a combination of lamotrigine and valproic acid

Lamotrigine and valproic acid are well-tolerated anticonvulsants, but frequently associated with severe cutaneous reactions, such as the Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis, when used in combination. We report a case of SJS likely induced by the use of a lamotrigine and val...

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Autores principales: Kavitha, S., Anbuchelvan, T., Mahalakshmi, V., Sathya, R., Sabarinath, T. R., Gururaj, N., Kalaivani, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Dental Science - Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606703/
https://www.ncbi.nlm.nih.gov/pubmed/26538961
http://dx.doi.org/10.4103/0975-7406.163545
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author Kavitha, S.
Anbuchelvan, T.
Mahalakshmi, V.
Sathya, R.
Sabarinath, T. R.
Gururaj, N.
Kalaivani, S.
author_facet Kavitha, S.
Anbuchelvan, T.
Mahalakshmi, V.
Sathya, R.
Sabarinath, T. R.
Gururaj, N.
Kalaivani, S.
author_sort Kavitha, S.
collection PubMed
description Lamotrigine and valproic acid are well-tolerated anticonvulsants, but frequently associated with severe cutaneous reactions, such as the Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis, when used in combination. We report a case of SJS likely induced by the use of a lamotrigine and valproic acid regimen and as a dental surgeon it is important to identify such lesion and report to pharmacovigilance.
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spelling pubmed-46067032015-11-04 Stevens–Johnson syndrome induced by a combination of lamotrigine and valproic acid Kavitha, S. Anbuchelvan, T. Mahalakshmi, V. Sathya, R. Sabarinath, T. R. Gururaj, N. Kalaivani, S. J Pharm Bioallied Sci Dental Science - Case Report Lamotrigine and valproic acid are well-tolerated anticonvulsants, but frequently associated with severe cutaneous reactions, such as the Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis, when used in combination. We report a case of SJS likely induced by the use of a lamotrigine and valproic acid regimen and as a dental surgeon it is important to identify such lesion and report to pharmacovigilance. Medknow Publications & Media Pvt Ltd 2015-08 /pmc/articles/PMC4606703/ /pubmed/26538961 http://dx.doi.org/10.4103/0975-7406.163545 Text en Copyright: © Journal of Pharmacy and Bioallied Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms
spellingShingle Dental Science - Case Report
Kavitha, S.
Anbuchelvan, T.
Mahalakshmi, V.
Sathya, R.
Sabarinath, T. R.
Gururaj, N.
Kalaivani, S.
Stevens–Johnson syndrome induced by a combination of lamotrigine and valproic acid
title Stevens–Johnson syndrome induced by a combination of lamotrigine and valproic acid
title_full Stevens–Johnson syndrome induced by a combination of lamotrigine and valproic acid
title_fullStr Stevens–Johnson syndrome induced by a combination of lamotrigine and valproic acid
title_full_unstemmed Stevens–Johnson syndrome induced by a combination of lamotrigine and valproic acid
title_short Stevens–Johnson syndrome induced by a combination of lamotrigine and valproic acid
title_sort stevens–johnson syndrome induced by a combination of lamotrigine and valproic acid
topic Dental Science - Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606703/
https://www.ncbi.nlm.nih.gov/pubmed/26538961
http://dx.doi.org/10.4103/0975-7406.163545
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