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Xenon Blocks Neuronal Injury Associated with Decompression
Despite state-of-the-art hyperbaric oxygen (HBO) treatment, about 30% of patients suffering neurologic decompression sickness (DCS) exhibit incomplete recovery. Since the mechanisms of neurologic DCS involve ischemic processes which result in excitotoxicity, it is likely that HBO in combination with...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606806/ https://www.ncbi.nlm.nih.gov/pubmed/26469983 http://dx.doi.org/10.1038/srep15093 |
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author | Blatteau, Jean-Eric David, Hélène N. Vallée, Nicolas Meckler, Cedric Demaistre, Sebastien Lambrechts, Kate Risso, Jean-Jacques Abraini, Jacques H. |
author_facet | Blatteau, Jean-Eric David, Hélène N. Vallée, Nicolas Meckler, Cedric Demaistre, Sebastien Lambrechts, Kate Risso, Jean-Jacques Abraini, Jacques H. |
author_sort | Blatteau, Jean-Eric |
collection | PubMed |
description | Despite state-of-the-art hyperbaric oxygen (HBO) treatment, about 30% of patients suffering neurologic decompression sickness (DCS) exhibit incomplete recovery. Since the mechanisms of neurologic DCS involve ischemic processes which result in excitotoxicity, it is likely that HBO in combination with an anti-excitotoxic treatment would improve the outcome in patients being treated for DCS. Therefore, in the present study, we investigated the effect of the noble gas xenon in an ex vivo model of neurologic DCS. Xenon has been shown to provide neuroprotection in multiple models of acute ischemic insults. Fast decompression compared to slow decompression induced an increase in lactate dehydrogenase (LDH), a well-known marker of sub-lethal cell injury. Post-decompression administration of xenon blocked the increase in LDH release induced by fast decompression. These data suggest that xenon could be an efficient additional treatment to HBO for the treatment of neurologic DCS. |
format | Online Article Text |
id | pubmed-4606806 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-46068062015-10-28 Xenon Blocks Neuronal Injury Associated with Decompression Blatteau, Jean-Eric David, Hélène N. Vallée, Nicolas Meckler, Cedric Demaistre, Sebastien Lambrechts, Kate Risso, Jean-Jacques Abraini, Jacques H. Sci Rep Article Despite state-of-the-art hyperbaric oxygen (HBO) treatment, about 30% of patients suffering neurologic decompression sickness (DCS) exhibit incomplete recovery. Since the mechanisms of neurologic DCS involve ischemic processes which result in excitotoxicity, it is likely that HBO in combination with an anti-excitotoxic treatment would improve the outcome in patients being treated for DCS. Therefore, in the present study, we investigated the effect of the noble gas xenon in an ex vivo model of neurologic DCS. Xenon has been shown to provide neuroprotection in multiple models of acute ischemic insults. Fast decompression compared to slow decompression induced an increase in lactate dehydrogenase (LDH), a well-known marker of sub-lethal cell injury. Post-decompression administration of xenon blocked the increase in LDH release induced by fast decompression. These data suggest that xenon could be an efficient additional treatment to HBO for the treatment of neurologic DCS. Nature Publishing Group 2015-10-15 /pmc/articles/PMC4606806/ /pubmed/26469983 http://dx.doi.org/10.1038/srep15093 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Blatteau, Jean-Eric David, Hélène N. Vallée, Nicolas Meckler, Cedric Demaistre, Sebastien Lambrechts, Kate Risso, Jean-Jacques Abraini, Jacques H. Xenon Blocks Neuronal Injury Associated with Decompression |
title | Xenon Blocks Neuronal Injury Associated with Decompression |
title_full | Xenon Blocks Neuronal Injury Associated with Decompression |
title_fullStr | Xenon Blocks Neuronal Injury Associated with Decompression |
title_full_unstemmed | Xenon Blocks Neuronal Injury Associated with Decompression |
title_short | Xenon Blocks Neuronal Injury Associated with Decompression |
title_sort | xenon blocks neuronal injury associated with decompression |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606806/ https://www.ncbi.nlm.nih.gov/pubmed/26469983 http://dx.doi.org/10.1038/srep15093 |
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