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Distinct roles of the RasGAP family proteins in C. elegans associative learning and memory
The Ras GTPase activating proteins (RasGAPs) are regulators of the conserved Ras/MAPK pathway. Various roles of some of the RasGAPs in learning and memory have been reported in different model systems, yet, there is no comprehensive study to characterize all gap genes in any organism. Here, using re...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606830/ https://www.ncbi.nlm.nih.gov/pubmed/26469632 http://dx.doi.org/10.1038/srep15084 |
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author | Gyurkó, M. Dávid Csermely, Péter Sőti, Csaba Steták, Attila |
author_facet | Gyurkó, M. Dávid Csermely, Péter Sőti, Csaba Steták, Attila |
author_sort | Gyurkó, M. Dávid |
collection | PubMed |
description | The Ras GTPase activating proteins (RasGAPs) are regulators of the conserved Ras/MAPK pathway. Various roles of some of the RasGAPs in learning and memory have been reported in different model systems, yet, there is no comprehensive study to characterize all gap genes in any organism. Here, using reverse genetics and neurobehavioural tests, we studied the role of all known genes of the rasgap family in C. elegans in associative learning and memory. We demonstrated that their proteins are implicated in different parts of the learning and memory processes. We show that gap-1 contribute redundantly with gap-3 to the chemosensation of volatile compounds, gap-1 plays a major role in associative learning, while gap-2 and gap-3 are predominantly required for short- and long-term associative memory. Our results also suggest that the C. elegans Ras orthologue let-60 is involved in multiple processes during learning and memory. Thus, we show that the different classes of RasGAP proteins are all involved in cognitive function and their complex interplay ensures the proper formation and storage of novel information in C. elegans. |
format | Online Article Text |
id | pubmed-4606830 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-46068302015-10-28 Distinct roles of the RasGAP family proteins in C. elegans associative learning and memory Gyurkó, M. Dávid Csermely, Péter Sőti, Csaba Steták, Attila Sci Rep Article The Ras GTPase activating proteins (RasGAPs) are regulators of the conserved Ras/MAPK pathway. Various roles of some of the RasGAPs in learning and memory have been reported in different model systems, yet, there is no comprehensive study to characterize all gap genes in any organism. Here, using reverse genetics and neurobehavioural tests, we studied the role of all known genes of the rasgap family in C. elegans in associative learning and memory. We demonstrated that their proteins are implicated in different parts of the learning and memory processes. We show that gap-1 contribute redundantly with gap-3 to the chemosensation of volatile compounds, gap-1 plays a major role in associative learning, while gap-2 and gap-3 are predominantly required for short- and long-term associative memory. Our results also suggest that the C. elegans Ras orthologue let-60 is involved in multiple processes during learning and memory. Thus, we show that the different classes of RasGAP proteins are all involved in cognitive function and their complex interplay ensures the proper formation and storage of novel information in C. elegans. Nature Publishing Group 2015-10-15 /pmc/articles/PMC4606830/ /pubmed/26469632 http://dx.doi.org/10.1038/srep15084 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Gyurkó, M. Dávid Csermely, Péter Sőti, Csaba Steták, Attila Distinct roles of the RasGAP family proteins in C. elegans associative learning and memory |
title | Distinct roles of the RasGAP family proteins in C. elegans associative learning and memory |
title_full | Distinct roles of the RasGAP family proteins in C. elegans associative learning and memory |
title_fullStr | Distinct roles of the RasGAP family proteins in C. elegans associative learning and memory |
title_full_unstemmed | Distinct roles of the RasGAP family proteins in C. elegans associative learning and memory |
title_short | Distinct roles of the RasGAP family proteins in C. elegans associative learning and memory |
title_sort | distinct roles of the rasgap family proteins in c. elegans associative learning and memory |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606830/ https://www.ncbi.nlm.nih.gov/pubmed/26469632 http://dx.doi.org/10.1038/srep15084 |
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