Comparative bactericidal activity of four fluoroquinolones against Pseudomonas aeruginosa isolated from chronic suppurative otitis media

BACKGROUND: The aim of the present study was to evaluate the bactericidal activity of four new fluoroquinolones against current isolates of Pseudomonas aeruginosa from the patients with chronic suppurative otitis media (CSOM). METHODS: We examined bactericidal activity of four types of fluoroquinolo...

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Autores principales: Ikeda, Katsuhisa, Misawa, Shigeki, Kusunoki, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607142/
https://www.ncbi.nlm.nih.gov/pubmed/26472937
http://dx.doi.org/10.1186/s12901-015-0018-9
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author Ikeda, Katsuhisa
Misawa, Shigeki
Kusunoki, Takeshi
author_facet Ikeda, Katsuhisa
Misawa, Shigeki
Kusunoki, Takeshi
author_sort Ikeda, Katsuhisa
collection PubMed
description BACKGROUND: The aim of the present study was to evaluate the bactericidal activity of four new fluoroquinolones against current isolates of Pseudomonas aeruginosa from the patients with chronic suppurative otitis media (CSOM). METHODS: We examined bactericidal activity of four types of fluoroquinolones, garenoxacin (GRNX), levofloxacin (LVFX), ciprofloxacin (CPFX) and sitafloxacin (STFX) against current isolates of P. aeruginosa (50 strains). RESULTS: STFX exhibited the most potent activity of both MIC(50) and MIC(90), followed by CPFX, LVFX, and GRNX. The number of GRNX-resistant strains was significantly greater than those of LVFX, CPFX, and STFX (P < 0.05). CONCLUSION: STFX showed the most potent activity against P. aeruginosa for recent pathogens recovered from CSOM as compared with the others, suggesting that the clinical application of topical STFX would be useful to prevent the emergence of resistant mutants of P. aeruginosa.
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spelling pubmed-46071422015-10-16 Comparative bactericidal activity of four fluoroquinolones against Pseudomonas aeruginosa isolated from chronic suppurative otitis media Ikeda, Katsuhisa Misawa, Shigeki Kusunoki, Takeshi BMC Ear Nose Throat Disord Research Article BACKGROUND: The aim of the present study was to evaluate the bactericidal activity of four new fluoroquinolones against current isolates of Pseudomonas aeruginosa from the patients with chronic suppurative otitis media (CSOM). METHODS: We examined bactericidal activity of four types of fluoroquinolones, garenoxacin (GRNX), levofloxacin (LVFX), ciprofloxacin (CPFX) and sitafloxacin (STFX) against current isolates of P. aeruginosa (50 strains). RESULTS: STFX exhibited the most potent activity of both MIC(50) and MIC(90), followed by CPFX, LVFX, and GRNX. The number of GRNX-resistant strains was significantly greater than those of LVFX, CPFX, and STFX (P < 0.05). CONCLUSION: STFX showed the most potent activity against P. aeruginosa for recent pathogens recovered from CSOM as compared with the others, suggesting that the clinical application of topical STFX would be useful to prevent the emergence of resistant mutants of P. aeruginosa. BioMed Central 2015-10-14 /pmc/articles/PMC4607142/ /pubmed/26472937 http://dx.doi.org/10.1186/s12901-015-0018-9 Text en © Ikeda et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Ikeda, Katsuhisa
Misawa, Shigeki
Kusunoki, Takeshi
Comparative bactericidal activity of four fluoroquinolones against Pseudomonas aeruginosa isolated from chronic suppurative otitis media
title Comparative bactericidal activity of four fluoroquinolones against Pseudomonas aeruginosa isolated from chronic suppurative otitis media
title_full Comparative bactericidal activity of four fluoroquinolones against Pseudomonas aeruginosa isolated from chronic suppurative otitis media
title_fullStr Comparative bactericidal activity of four fluoroquinolones against Pseudomonas aeruginosa isolated from chronic suppurative otitis media
title_full_unstemmed Comparative bactericidal activity of four fluoroquinolones against Pseudomonas aeruginosa isolated from chronic suppurative otitis media
title_short Comparative bactericidal activity of four fluoroquinolones against Pseudomonas aeruginosa isolated from chronic suppurative otitis media
title_sort comparative bactericidal activity of four fluoroquinolones against pseudomonas aeruginosa isolated from chronic suppurative otitis media
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607142/
https://www.ncbi.nlm.nih.gov/pubmed/26472937
http://dx.doi.org/10.1186/s12901-015-0018-9
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