Rapid Antiretroviral Therapy Initiation for Women in an HIV-1 Prevention Clinical Trial Experiencing Primary HIV-1 Infection during Pregnancy or Breastfeeding

During an HIV-1 prevention clinical trial in East Africa, we observed 16 cases of primary HIV-1 infection in women coincident with pregnancy or breastfeeding. Nine of eleven pregnant women initiated rapid combination antiretroviral therapy (ART), despite having CD4 counts exceeding national criteria...

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Detalles Bibliográficos
Autores principales: Morrison, Susan, John-Stewart, Grace, Egessa, John J., Mubezi, Sezi, Kusemererwa, Sylvia, Bii, Dennis K., Bulya, Nulu, Mugume, Francis, Campbell, James D., Wangisi, Jonathan, Bukusi, Elizabeth A., Celum, Connie, Baeten, Jared M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607156/
https://www.ncbi.nlm.nih.gov/pubmed/26469986
http://dx.doi.org/10.1371/journal.pone.0140773
Descripción
Sumario:During an HIV-1 prevention clinical trial in East Africa, we observed 16 cases of primary HIV-1 infection in women coincident with pregnancy or breastfeeding. Nine of eleven pregnant women initiated rapid combination antiretroviral therapy (ART), despite having CD4 counts exceeding national criteria for ART initiation; breastfeeding women initiated ART or replacement feeding. Rapid ART initiation during primary HIV-1 infection during pregnancy and breastfeeding is feasible in this setting.

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