Rapid Antiretroviral Therapy Initiation for Women in an HIV-1 Prevention Clinical Trial Experiencing Primary HIV-1 Infection during Pregnancy or Breastfeeding

During an HIV-1 prevention clinical trial in East Africa, we observed 16 cases of primary HIV-1 infection in women coincident with pregnancy or breastfeeding. Nine of eleven pregnant women initiated rapid combination antiretroviral therapy (ART), despite having CD4 counts exceeding national criteria...

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Autores principales: Morrison, Susan, John-Stewart, Grace, Egessa, John J., Mubezi, Sezi, Kusemererwa, Sylvia, Bii, Dennis K., Bulya, Nulu, Mugume, Francis, Campbell, James D., Wangisi, Jonathan, Bukusi, Elizabeth A., Celum, Connie, Baeten, Jared M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607156/
https://www.ncbi.nlm.nih.gov/pubmed/26469986
http://dx.doi.org/10.1371/journal.pone.0140773
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author Morrison, Susan
John-Stewart, Grace
Egessa, John J.
Mubezi, Sezi
Kusemererwa, Sylvia
Bii, Dennis K.
Bulya, Nulu
Mugume, Francis
Campbell, James D.
Wangisi, Jonathan
Bukusi, Elizabeth A.
Celum, Connie
Baeten, Jared M.
author_facet Morrison, Susan
John-Stewart, Grace
Egessa, John J.
Mubezi, Sezi
Kusemererwa, Sylvia
Bii, Dennis K.
Bulya, Nulu
Mugume, Francis
Campbell, James D.
Wangisi, Jonathan
Bukusi, Elizabeth A.
Celum, Connie
Baeten, Jared M.
author_sort Morrison, Susan
collection PubMed
description During an HIV-1 prevention clinical trial in East Africa, we observed 16 cases of primary HIV-1 infection in women coincident with pregnancy or breastfeeding. Nine of eleven pregnant women initiated rapid combination antiretroviral therapy (ART), despite having CD4 counts exceeding national criteria for ART initiation; breastfeeding women initiated ART or replacement feeding. Rapid ART initiation during primary HIV-1 infection during pregnancy and breastfeeding is feasible in this setting.
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spelling pubmed-46071562015-10-29 Rapid Antiretroviral Therapy Initiation for Women in an HIV-1 Prevention Clinical Trial Experiencing Primary HIV-1 Infection during Pregnancy or Breastfeeding Morrison, Susan John-Stewart, Grace Egessa, John J. Mubezi, Sezi Kusemererwa, Sylvia Bii, Dennis K. Bulya, Nulu Mugume, Francis Campbell, James D. Wangisi, Jonathan Bukusi, Elizabeth A. Celum, Connie Baeten, Jared M. PLoS One Research Article During an HIV-1 prevention clinical trial in East Africa, we observed 16 cases of primary HIV-1 infection in women coincident with pregnancy or breastfeeding. Nine of eleven pregnant women initiated rapid combination antiretroviral therapy (ART), despite having CD4 counts exceeding national criteria for ART initiation; breastfeeding women initiated ART or replacement feeding. Rapid ART initiation during primary HIV-1 infection during pregnancy and breastfeeding is feasible in this setting. Public Library of Science 2015-10-15 /pmc/articles/PMC4607156/ /pubmed/26469986 http://dx.doi.org/10.1371/journal.pone.0140773 Text en © 2015 Morrison et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Morrison, Susan
John-Stewart, Grace
Egessa, John J.
Mubezi, Sezi
Kusemererwa, Sylvia
Bii, Dennis K.
Bulya, Nulu
Mugume, Francis
Campbell, James D.
Wangisi, Jonathan
Bukusi, Elizabeth A.
Celum, Connie
Baeten, Jared M.
Rapid Antiretroviral Therapy Initiation for Women in an HIV-1 Prevention Clinical Trial Experiencing Primary HIV-1 Infection during Pregnancy or Breastfeeding
title Rapid Antiretroviral Therapy Initiation for Women in an HIV-1 Prevention Clinical Trial Experiencing Primary HIV-1 Infection during Pregnancy or Breastfeeding
title_full Rapid Antiretroviral Therapy Initiation for Women in an HIV-1 Prevention Clinical Trial Experiencing Primary HIV-1 Infection during Pregnancy or Breastfeeding
title_fullStr Rapid Antiretroviral Therapy Initiation for Women in an HIV-1 Prevention Clinical Trial Experiencing Primary HIV-1 Infection during Pregnancy or Breastfeeding
title_full_unstemmed Rapid Antiretroviral Therapy Initiation for Women in an HIV-1 Prevention Clinical Trial Experiencing Primary HIV-1 Infection during Pregnancy or Breastfeeding
title_short Rapid Antiretroviral Therapy Initiation for Women in an HIV-1 Prevention Clinical Trial Experiencing Primary HIV-1 Infection during Pregnancy or Breastfeeding
title_sort rapid antiretroviral therapy initiation for women in an hiv-1 prevention clinical trial experiencing primary hiv-1 infection during pregnancy or breastfeeding
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607156/
https://www.ncbi.nlm.nih.gov/pubmed/26469986
http://dx.doi.org/10.1371/journal.pone.0140773
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