Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092

As a critical component in the PI3K/AKT/mTOR pathway, AKT has become an attractive target for therapeutic intervention. ARQ 092 and a next generation AKT inhibitor, ARQ 751 are selective, allosteric, pan-AKT and AKT1-E17K mutant inhibitors that potently inhibit phosphorylation of AKT. Biochemical an...

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Detalles Bibliográficos
Autores principales: Yu, Yi, Savage, Ronald E., Eathiraj, Sudharshan, Meade, Justin, Wick, Michael J., Hall, Terence, Abbadessa, Giovanni, Schwartz, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607407/
https://www.ncbi.nlm.nih.gov/pubmed/26469692
http://dx.doi.org/10.1371/journal.pone.0140479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607407/
https://www.ncbi.nlm.nih.gov/pubmed/26469692
http://dx.doi.org/10.1371/journal.pone.0140479

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