The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells

Although glucose uniquely stimulates proinsulin biosynthesis in β cells, surprisingly little is known of the underlying mechanism(s). Here, we demonstrate that glucose activates the unfolded protein response transducer inositol-requiring enzyme 1 alpha (IRE1α) to initiate X-box-binding protein 1 (Xb...

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Detalles Bibliográficos
Autores principales: Hassler, Justin R., Scheuner, Donalyn L., Wang, Shiyu, Han, Jaeseok, Kodali, Vamsi K., Li, Philip, Nguyen, Julie, George, Jenny S., Davis, Cory, Wu, Shengyang P., Bai, Yongsheng, Sartor, Maureen, Cavalcoli, James, Malhi, Harmeet, Baudouin, Gregory, Zhang, Yaoyang, Yates III, John R., Itkin-Ansari, Pamela, Volkmann, Niels, Kaufman, Randal J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607427/
https://www.ncbi.nlm.nih.gov/pubmed/26469762
http://dx.doi.org/10.1371/journal.pbio.1002277

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