Predicting Pharmacodynamic Drug-Drug Interactions through Signaling Propagation Interference on Protein-Protein Interaction Networks

As pharmacodynamic drug-drug interactions (PD DDIs) could lead to severe adverse effects in patients, it is important to identify potential PD DDIs in drug development. The signaling starting from drug targets is propagated through protein-protein interaction (PPI) networks. PD DDIs could occur by c...

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Detalles Bibliográficos
Autores principales: Park, Kyunghyun, Kim, Docyong, Ha, Suhyun, Lee, Doheon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607460/
https://www.ncbi.nlm.nih.gov/pubmed/26469276
http://dx.doi.org/10.1371/journal.pone.0140816

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