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Modeling of Longitudinal Changes in Left Ventricular Dimensions among Female Adolescent Runners

PURPOSE: Left ventricular (LV) enlargement has been linked to sudden cardiac death among young athletes. This study aimed to model the effect of long-term incessant endurance training on LV dimensions in female adolescent runners. METHODS: Japanese female adolescent competitive distance runners (n =...

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Autores principales: Kinoshita, Norimitsu, Katsukawa, Fuminori, Yamazaki, Hajime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607476/
https://www.ncbi.nlm.nih.gov/pubmed/26469336
http://dx.doi.org/10.1371/journal.pone.0140573
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author Kinoshita, Norimitsu
Katsukawa, Fuminori
Yamazaki, Hajime
author_facet Kinoshita, Norimitsu
Katsukawa, Fuminori
Yamazaki, Hajime
author_sort Kinoshita, Norimitsu
collection PubMed
description PURPOSE: Left ventricular (LV) enlargement has been linked to sudden cardiac death among young athletes. This study aimed to model the effect of long-term incessant endurance training on LV dimensions in female adolescent runners. METHODS: Japanese female adolescent competitive distance runners (n = 36, age: 15 years, height: 158.1 ± 4.6 cm, weight: 44.7 ± 6.1 kg, percent body fat: 17.0 ± 5.2%) underwent echocardiography and underwater weighing every 6 months for 3 years. Since the measurement occasions varied across subjects, multilevel analysis was used for curvilinear modeling of changes in running performance (velocities in 1500 m and 3000 m track race), maximal oxygen uptake (VO(2)max), body composition, and LV dimensions. RESULTS: Initially, LV end-diastolic dimension (LVEDd) and LV mass were 47.0 ± 3.0 mm and 122.6 ± 15.7 g, respectively. Running performance and VO(2)max improved along with the training duration. The trends of changes in fat-free mass (FFM) and LVEDd were similarly best described by quadratic polynomials. LVEDd did not change over time in the model including FFM as a covariate. Increases in LV wall thicknesses were minimal and independent of FFM. LV mass increased according to a quadratic polynomial trend even after adjusting for FFM. CONCLUSIONS: FFM was an important factor determining changes in LVEDd and LV mass. Although running performance and VO(2)max were improved by continued endurance training, further LV cavity enlargement hardly occurred beyond FFM gain in these adolescent female runners, who already demonstrated a large LVEDd.
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spelling pubmed-46074762015-10-29 Modeling of Longitudinal Changes in Left Ventricular Dimensions among Female Adolescent Runners Kinoshita, Norimitsu Katsukawa, Fuminori Yamazaki, Hajime PLoS One Research Article PURPOSE: Left ventricular (LV) enlargement has been linked to sudden cardiac death among young athletes. This study aimed to model the effect of long-term incessant endurance training on LV dimensions in female adolescent runners. METHODS: Japanese female adolescent competitive distance runners (n = 36, age: 15 years, height: 158.1 ± 4.6 cm, weight: 44.7 ± 6.1 kg, percent body fat: 17.0 ± 5.2%) underwent echocardiography and underwater weighing every 6 months for 3 years. Since the measurement occasions varied across subjects, multilevel analysis was used for curvilinear modeling of changes in running performance (velocities in 1500 m and 3000 m track race), maximal oxygen uptake (VO(2)max), body composition, and LV dimensions. RESULTS: Initially, LV end-diastolic dimension (LVEDd) and LV mass were 47.0 ± 3.0 mm and 122.6 ± 15.7 g, respectively. Running performance and VO(2)max improved along with the training duration. The trends of changes in fat-free mass (FFM) and LVEDd were similarly best described by quadratic polynomials. LVEDd did not change over time in the model including FFM as a covariate. Increases in LV wall thicknesses were minimal and independent of FFM. LV mass increased according to a quadratic polynomial trend even after adjusting for FFM. CONCLUSIONS: FFM was an important factor determining changes in LVEDd and LV mass. Although running performance and VO(2)max were improved by continued endurance training, further LV cavity enlargement hardly occurred beyond FFM gain in these adolescent female runners, who already demonstrated a large LVEDd. Public Library of Science 2015-10-15 /pmc/articles/PMC4607476/ /pubmed/26469336 http://dx.doi.org/10.1371/journal.pone.0140573 Text en © 2015 Kinoshita et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kinoshita, Norimitsu
Katsukawa, Fuminori
Yamazaki, Hajime
Modeling of Longitudinal Changes in Left Ventricular Dimensions among Female Adolescent Runners
title Modeling of Longitudinal Changes in Left Ventricular Dimensions among Female Adolescent Runners
title_full Modeling of Longitudinal Changes in Left Ventricular Dimensions among Female Adolescent Runners
title_fullStr Modeling of Longitudinal Changes in Left Ventricular Dimensions among Female Adolescent Runners
title_full_unstemmed Modeling of Longitudinal Changes in Left Ventricular Dimensions among Female Adolescent Runners
title_short Modeling of Longitudinal Changes in Left Ventricular Dimensions among Female Adolescent Runners
title_sort modeling of longitudinal changes in left ventricular dimensions among female adolescent runners
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607476/
https://www.ncbi.nlm.nih.gov/pubmed/26469336
http://dx.doi.org/10.1371/journal.pone.0140573
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