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Integrating Kinetic Model of E. coli with Genome Scale Metabolic Fluxes Overcomes Its Open System Problem and Reveals Bistability in Central Metabolism

An understanding of the dynamics of the metabolic profile of a bacterial cell is sought from a dynamical systems analysis of kinetic models. This modelling formalism relies on a deterministic mathematical description of enzyme kinetics and their metabolite regulation. However, it is severely impeded...

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Detalles Bibliográficos
Autores principales:	Mannan, Ahmad A., Toya, Yoshihiro, Shimizu, Kazuyuki, McFadden, Johnjoe, Kierzek, Andrzej M., Rocco, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607504/ https://www.ncbi.nlm.nih.gov/pubmed/26469081 http://dx.doi.org/10.1371/journal.pone.0139507

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