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Influence of different boost techniques on radiation dose to the left anterior descending coronary artery

PURPOSE: The purpose of this study is to compare the dosimetry of electron beam (EB) plans and three-dimensional helical tomotherapy (3DHT) plans for the patients with left-sided breast cancer, who underwent breast conserving surgery. MATERIALS AND METHODS: We selected total of 15 patients based on...

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Autores principales: Park, Kawngwoo, Lee, Yongha, Cha, Jihye, You, Sei Hwan, Kim, Sunghyun, Lee, Jong Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Radiation Oncology 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607578/
https://www.ncbi.nlm.nih.gov/pubmed/26484308
http://dx.doi.org/10.3857/roj.2015.33.3.242
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author Park, Kawngwoo
Lee, Yongha
Cha, Jihye
You, Sei Hwan
Kim, Sunghyun
Lee, Jong Young
author_facet Park, Kawngwoo
Lee, Yongha
Cha, Jihye
You, Sei Hwan
Kim, Sunghyun
Lee, Jong Young
author_sort Park, Kawngwoo
collection PubMed
description PURPOSE: The purpose of this study is to compare the dosimetry of electron beam (EB) plans and three-dimensional helical tomotherapy (3DHT) plans for the patients with left-sided breast cancer, who underwent breast conserving surgery. MATERIALS AND METHODS: We selected total of 15 patients based on the location of tumor, as following subsite: subareolar, upper outer, upper inner, lower lateral, and lower medial quadrants. The clinical target volume (CTV) was defined as the area of architectural distortion surrounded by surgical clip plus 1 cm margin. The conformity index (CI), homogeneity index (HI), quality of coverage (QC) and dose-volume parameters for the CTV, and organ at risk (OAR) were calculated. The following treatment techniques were assessed: single conformal EB plans; 3DHT plans with directional block of left anterior descending artery (LAD); and 3DHT plans with complete block of LAD. RESULTS: 3DHT plans, regardless of type of LAD block, showed significantly better CI, HI, and QC for the CTVs, compared with the EB plans. However, 3DHT plans showed increase in the V(1Gy) at skin, left lung, and left breast. In terms of LAD, 3DHT plans with complete block of LAD showed extremely low dose, while dose increase in other OARs were observed, when compared with other plans. EB plans showed the worst conformity at upper outer quadrants of tumor bed site. CONCLUSION: 3DHT plans offer more favorable dose distributions to LAD, as well as improved target coverage in comparison with EB plans.
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spelling pubmed-46075782015-10-19 Influence of different boost techniques on radiation dose to the left anterior descending coronary artery Park, Kawngwoo Lee, Yongha Cha, Jihye You, Sei Hwan Kim, Sunghyun Lee, Jong Young Radiat Oncol J Original Article PURPOSE: The purpose of this study is to compare the dosimetry of electron beam (EB) plans and three-dimensional helical tomotherapy (3DHT) plans for the patients with left-sided breast cancer, who underwent breast conserving surgery. MATERIALS AND METHODS: We selected total of 15 patients based on the location of tumor, as following subsite: subareolar, upper outer, upper inner, lower lateral, and lower medial quadrants. The clinical target volume (CTV) was defined as the area of architectural distortion surrounded by surgical clip plus 1 cm margin. The conformity index (CI), homogeneity index (HI), quality of coverage (QC) and dose-volume parameters for the CTV, and organ at risk (OAR) were calculated. The following treatment techniques were assessed: single conformal EB plans; 3DHT plans with directional block of left anterior descending artery (LAD); and 3DHT plans with complete block of LAD. RESULTS: 3DHT plans, regardless of type of LAD block, showed significantly better CI, HI, and QC for the CTVs, compared with the EB plans. However, 3DHT plans showed increase in the V(1Gy) at skin, left lung, and left breast. In terms of LAD, 3DHT plans with complete block of LAD showed extremely low dose, while dose increase in other OARs were observed, when compared with other plans. EB plans showed the worst conformity at upper outer quadrants of tumor bed site. CONCLUSION: 3DHT plans offer more favorable dose distributions to LAD, as well as improved target coverage in comparison with EB plans. The Korean Society for Radiation Oncology 2015-09 2015-09-30 /pmc/articles/PMC4607578/ /pubmed/26484308 http://dx.doi.org/10.3857/roj.2015.33.3.242 Text en Copyright © 2015. The Korean Society for Radiation Oncology http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Park, Kawngwoo
Lee, Yongha
Cha, Jihye
You, Sei Hwan
Kim, Sunghyun
Lee, Jong Young
Influence of different boost techniques on radiation dose to the left anterior descending coronary artery
title Influence of different boost techniques on radiation dose to the left anterior descending coronary artery
title_full Influence of different boost techniques on radiation dose to the left anterior descending coronary artery
title_fullStr Influence of different boost techniques on radiation dose to the left anterior descending coronary artery
title_full_unstemmed Influence of different boost techniques on radiation dose to the left anterior descending coronary artery
title_short Influence of different boost techniques on radiation dose to the left anterior descending coronary artery
title_sort influence of different boost techniques on radiation dose to the left anterior descending coronary artery
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607578/
https://www.ncbi.nlm.nih.gov/pubmed/26484308
http://dx.doi.org/10.3857/roj.2015.33.3.242
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