Prevalence of neurogenetic disorders in the North of England

OBJECTIVE: Genetic disorders enter the differential diagnosis of common neurologic diseases, but their overall prevalence is not known. We set out to determine their minimum prevalence. METHODS: Meta-analysis of epidemiologic data gathered from the same geographic region in the North of England. RES...

Descripción completa

Detalles Bibliográficos
Autores principales: Bargiela, David, Yu-Wai-Man, Patrick, Keogh, Michael, Horvath, Rita, Chinnery, Patrick F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607600/
https://www.ncbi.nlm.nih.gov/pubmed/26341866
http://dx.doi.org/10.1212/WNL.0000000000001995
_version_ 1782395536393895936
author Bargiela, David
Yu-Wai-Man, Patrick
Keogh, Michael
Horvath, Rita
Chinnery, Patrick F.
author_facet Bargiela, David
Yu-Wai-Man, Patrick
Keogh, Michael
Horvath, Rita
Chinnery, Patrick F.
author_sort Bargiela, David
collection PubMed
description OBJECTIVE: Genetic disorders enter the differential diagnosis of common neurologic diseases, but their overall prevalence is not known. We set out to determine their minimum prevalence. METHODS: Meta-analysis of epidemiologic data gathered from the same geographic region in the North of England. RESULTS: Monogenic neurologic disorders affect at least 90.9/100,000 (95% confidence interval 87.6–94.3), or 1 in 1,100 of the population in Northern England. CONCLUSION: As a group, neurogenetic disorders are not rare. These findings have implications for clinical service delivery.
format Online
Article
Text
id pubmed-4607600
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-46076002015-10-29 Prevalence of neurogenetic disorders in the North of England Bargiela, David Yu-Wai-Man, Patrick Keogh, Michael Horvath, Rita Chinnery, Patrick F. Neurology Article OBJECTIVE: Genetic disorders enter the differential diagnosis of common neurologic diseases, but their overall prevalence is not known. We set out to determine their minimum prevalence. METHODS: Meta-analysis of epidemiologic data gathered from the same geographic region in the North of England. RESULTS: Monogenic neurologic disorders affect at least 90.9/100,000 (95% confidence interval 87.6–94.3), or 1 in 1,100 of the population in Northern England. CONCLUSION: As a group, neurogenetic disorders are not rare. These findings have implications for clinical service delivery. Lippincott Williams & Wilkins 2015-10-06 /pmc/articles/PMC4607600/ /pubmed/26341866 http://dx.doi.org/10.1212/WNL.0000000000001995 Text en © 2015 American Academy of Neurology This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Bargiela, David
Yu-Wai-Man, Patrick
Keogh, Michael
Horvath, Rita
Chinnery, Patrick F.
Prevalence of neurogenetic disorders in the North of England
title Prevalence of neurogenetic disorders in the North of England
title_full Prevalence of neurogenetic disorders in the North of England
title_fullStr Prevalence of neurogenetic disorders in the North of England
title_full_unstemmed Prevalence of neurogenetic disorders in the North of England
title_short Prevalence of neurogenetic disorders in the North of England
title_sort prevalence of neurogenetic disorders in the north of england
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607600/
https://www.ncbi.nlm.nih.gov/pubmed/26341866
http://dx.doi.org/10.1212/WNL.0000000000001995
work_keys_str_mv AT bargieladavid prevalenceofneurogeneticdisordersinthenorthofengland
AT yuwaimanpatrick prevalenceofneurogeneticdisordersinthenorthofengland
AT keoghmichael prevalenceofneurogeneticdisordersinthenorthofengland
AT horvathrita prevalenceofneurogeneticdisordersinthenorthofengland
AT chinnerypatrickf prevalenceofneurogeneticdisordersinthenorthofengland

Ejemplares similares