Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla

ABSTRACT: Five new hybrid monoterpenoid indole alkaloids bearing an unusual 2,2-dimethyl-4-oxopiperidin-6-yl moiety, namely rauvotetraphyllines F–H (1, 3, 4), 17-epi-rauvotetraphylline F (2) and 21-epi-rauvotetraphylline H (5), were isolated from the aerial parts of Rauvolfia tetraphylla. Their stru...

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Detalles Bibliográficos
Autores principales: Gao, Yuan, Zhou, Dong-Sheng, Hai, Ping, Li, Yan, Wang, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607677/
https://www.ncbi.nlm.nih.gov/pubmed/26416155
http://dx.doi.org/10.1007/s13659-015-0074-2
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author Gao, Yuan
Zhou, Dong-Sheng
Hai, Ping
Li, Yan
Wang, Fei
author_facet Gao, Yuan
Zhou, Dong-Sheng
Hai, Ping
Li, Yan
Wang, Fei
author_sort Gao, Yuan
collection PubMed
description ABSTRACT: Five new hybrid monoterpenoid indole alkaloids bearing an unusual 2,2-dimethyl-4-oxopiperidin-6-yl moiety, namely rauvotetraphyllines F–H (1, 3, 4), 17-epi-rauvotetraphylline F (2) and 21-epi-rauvotetraphylline H (5), were isolated from the aerial parts of Rauvolfia tetraphylla. Their structures were established by extensive spectroscopic analysis. The new alkaloids were evaluated for their cytotoxicity in vitro against five human cancer cell lines. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-015-0074-2) contains supplementary material, which is available to authorized users.
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spelling pubmed-46076772015-10-20 Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla Gao, Yuan Zhou, Dong-Sheng Hai, Ping Li, Yan Wang, Fei Nat Prod Bioprospect Original Article ABSTRACT: Five new hybrid monoterpenoid indole alkaloids bearing an unusual 2,2-dimethyl-4-oxopiperidin-6-yl moiety, namely rauvotetraphyllines F–H (1, 3, 4), 17-epi-rauvotetraphylline F (2) and 21-epi-rauvotetraphylline H (5), were isolated from the aerial parts of Rauvolfia tetraphylla. Their structures were established by extensive spectroscopic analysis. The new alkaloids were evaluated for their cytotoxicity in vitro against five human cancer cell lines. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-015-0074-2) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2015-09-29 /pmc/articles/PMC4607677/ /pubmed/26416155 http://dx.doi.org/10.1007/s13659-015-0074-2 Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Gao, Yuan
Zhou, Dong-Sheng
Hai, Ping
Li, Yan
Wang, Fei
Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla
title Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla
title_full Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla
title_fullStr Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla
title_full_unstemmed Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla
title_short Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla
title_sort hybrid monoterpenoid indole alkaloids obtained as artifacts from rauvolfia tetraphylla
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607677/
https://www.ncbi.nlm.nih.gov/pubmed/26416155
http://dx.doi.org/10.1007/s13659-015-0074-2
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