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Total Synthesis of Lignan Lactone (–)-Hinokinin

This research paper is aimed at studying the total synthesis of pharmacologically active lignan (–)-hinokinin. The synthesis features a three-step cascade reaction involving highly stereoselective Michael addition, anion-oxidative hydroxylation, and oxygen anion cyclization to construct the pivotal...

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Detalles Bibliográficos
Autores principales: Zhou, Qi-Long, Wang, Hui-Jing, Tang, Pei, Song, Hao, Qin, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607678/
https://www.ncbi.nlm.nih.gov/pubmed/26458924
http://dx.doi.org/10.1007/s13659-015-0073-3
Descripción
Sumario:This research paper is aimed at studying the total synthesis of pharmacologically active lignan (–)-hinokinin. The synthesis features a three-step cascade reaction involving highly stereoselective Michael addition, anion-oxidative hydroxylation, and oxygen anion cyclization to construct the pivotal butyrolactonimidate intermediate. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-015-0073-3) contains supplementary material, which is available to authorized users.