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Delta hepatitis-related thyroid disease: a unique phenomenon

INTRODUCTION: Hepatitis delta virus (HDV) infection is a serious health problem worldwide. Thyroid disturbances represent a major limitation to the efficacy of interferon treatment targeting chronic HDV (C-HDV) infection. Moreover, pre-treatment thyroid diseases may be influenced by interferon thera...

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Autores principales: Suvak, Burak, Dulger, Ahmet Cumhur, Aykaç, Mehmet Coskun, Gonullu, Hayriye, Gonullu, Edip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607693/
https://www.ncbi.nlm.nih.gov/pubmed/26516384
http://dx.doi.org/10.5114/pg.2015.49687
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author Suvak, Burak
Dulger, Ahmet Cumhur
Aykaç, Mehmet Coskun
Gonullu, Hayriye
Gonullu, Edip
author_facet Suvak, Burak
Dulger, Ahmet Cumhur
Aykaç, Mehmet Coskun
Gonullu, Hayriye
Gonullu, Edip
author_sort Suvak, Burak
collection PubMed
description INTRODUCTION: Hepatitis delta virus (HDV) infection is a serious health problem worldwide. Thyroid disturbances represent a major limitation to the efficacy of interferon treatment targeting chronic HDV (C-HDV) infection. Moreover, pre-treatment thyroid diseases may be influenced by interferon therapy. Despite this, the characteristic features of the thyroid diseases in C-HDV patients remain poorly characterised. AIM: To determine the prevalence of thyroid diseases and evaluate the impact of delta hepatitis on thyroid function tests. MATERIAL AND METHODS: We retrospectively reviewed the charts of 127 hepatitis C virus (HCV)-negative adults, treatment-naive outpatients with C-HDV, between July 2013 and July 2014. Thyroid-stimulating hormone (TSH) and thyroid antibodies (TAbs) including anti-thyroid peroxidase antibodies (anti-TPO), liver transaminases, and other routine laboratory tests were conducted during the study period. RESULTS: A total of 127 C-HDV patients (female 52.9%, mean age 54.5 ±8.01 years) were enrolled. The rate of hypothyroidism, defined as a TSH level above 10 IU/l, was 4.7%. No patient had hyperthyroidism. Both elevated levels of liver transaminases and HDV ribonucleic acid (HDV-RNA) were positively correlated with high levels of thyroid autoantibodies. CONCLUSIONS: The rate of hypothyroidism is higher than the rate of hyperthyroidism at baseline. Most remarkably, for the first time we discovered a correlation between disturbed thyroid autoantibodies and elevated liver transaminases as well as high HDV-RNA levels even in euthyroid delta hepatitis patients. But in order to have an adequate understanding of such correlations, further studies are needed.
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spelling pubmed-46076932015-10-29 Delta hepatitis-related thyroid disease: a unique phenomenon Suvak, Burak Dulger, Ahmet Cumhur Aykaç, Mehmet Coskun Gonullu, Hayriye Gonullu, Edip Prz Gastroenterol Original Paper INTRODUCTION: Hepatitis delta virus (HDV) infection is a serious health problem worldwide. Thyroid disturbances represent a major limitation to the efficacy of interferon treatment targeting chronic HDV (C-HDV) infection. Moreover, pre-treatment thyroid diseases may be influenced by interferon therapy. Despite this, the characteristic features of the thyroid diseases in C-HDV patients remain poorly characterised. AIM: To determine the prevalence of thyroid diseases and evaluate the impact of delta hepatitis on thyroid function tests. MATERIAL AND METHODS: We retrospectively reviewed the charts of 127 hepatitis C virus (HCV)-negative adults, treatment-naive outpatients with C-HDV, between July 2013 and July 2014. Thyroid-stimulating hormone (TSH) and thyroid antibodies (TAbs) including anti-thyroid peroxidase antibodies (anti-TPO), liver transaminases, and other routine laboratory tests were conducted during the study period. RESULTS: A total of 127 C-HDV patients (female 52.9%, mean age 54.5 ±8.01 years) were enrolled. The rate of hypothyroidism, defined as a TSH level above 10 IU/l, was 4.7%. No patient had hyperthyroidism. Both elevated levels of liver transaminases and HDV ribonucleic acid (HDV-RNA) were positively correlated with high levels of thyroid autoantibodies. CONCLUSIONS: The rate of hypothyroidism is higher than the rate of hyperthyroidism at baseline. Most remarkably, for the first time we discovered a correlation between disturbed thyroid autoantibodies and elevated liver transaminases as well as high HDV-RNA levels even in euthyroid delta hepatitis patients. But in order to have an adequate understanding of such correlations, further studies are needed. Termedia Publishing House 2015-03-10 2015 /pmc/articles/PMC4607693/ /pubmed/26516384 http://dx.doi.org/10.5114/pg.2015.49687 Text en Copyright © 2015 Termedia http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Paper
Suvak, Burak
Dulger, Ahmet Cumhur
Aykaç, Mehmet Coskun
Gonullu, Hayriye
Gonullu, Edip
Delta hepatitis-related thyroid disease: a unique phenomenon
title Delta hepatitis-related thyroid disease: a unique phenomenon
title_full Delta hepatitis-related thyroid disease: a unique phenomenon
title_fullStr Delta hepatitis-related thyroid disease: a unique phenomenon
title_full_unstemmed Delta hepatitis-related thyroid disease: a unique phenomenon
title_short Delta hepatitis-related thyroid disease: a unique phenomenon
title_sort delta hepatitis-related thyroid disease: a unique phenomenon
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607693/
https://www.ncbi.nlm.nih.gov/pubmed/26516384
http://dx.doi.org/10.5114/pg.2015.49687
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