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Delta hepatitis-related thyroid disease: a unique phenomenon
INTRODUCTION: Hepatitis delta virus (HDV) infection is a serious health problem worldwide. Thyroid disturbances represent a major limitation to the efficacy of interferon treatment targeting chronic HDV (C-HDV) infection. Moreover, pre-treatment thyroid diseases may be influenced by interferon thera...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607693/ https://www.ncbi.nlm.nih.gov/pubmed/26516384 http://dx.doi.org/10.5114/pg.2015.49687 |
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author | Suvak, Burak Dulger, Ahmet Cumhur Aykaç, Mehmet Coskun Gonullu, Hayriye Gonullu, Edip |
author_facet | Suvak, Burak Dulger, Ahmet Cumhur Aykaç, Mehmet Coskun Gonullu, Hayriye Gonullu, Edip |
author_sort | Suvak, Burak |
collection | PubMed |
description | INTRODUCTION: Hepatitis delta virus (HDV) infection is a serious health problem worldwide. Thyroid disturbances represent a major limitation to the efficacy of interferon treatment targeting chronic HDV (C-HDV) infection. Moreover, pre-treatment thyroid diseases may be influenced by interferon therapy. Despite this, the characteristic features of the thyroid diseases in C-HDV patients remain poorly characterised. AIM: To determine the prevalence of thyroid diseases and evaluate the impact of delta hepatitis on thyroid function tests. MATERIAL AND METHODS: We retrospectively reviewed the charts of 127 hepatitis C virus (HCV)-negative adults, treatment-naive outpatients with C-HDV, between July 2013 and July 2014. Thyroid-stimulating hormone (TSH) and thyroid antibodies (TAbs) including anti-thyroid peroxidase antibodies (anti-TPO), liver transaminases, and other routine laboratory tests were conducted during the study period. RESULTS: A total of 127 C-HDV patients (female 52.9%, mean age 54.5 ±8.01 years) were enrolled. The rate of hypothyroidism, defined as a TSH level above 10 IU/l, was 4.7%. No patient had hyperthyroidism. Both elevated levels of liver transaminases and HDV ribonucleic acid (HDV-RNA) were positively correlated with high levels of thyroid autoantibodies. CONCLUSIONS: The rate of hypothyroidism is higher than the rate of hyperthyroidism at baseline. Most remarkably, for the first time we discovered a correlation between disturbed thyroid autoantibodies and elevated liver transaminases as well as high HDV-RNA levels even in euthyroid delta hepatitis patients. But in order to have an adequate understanding of such correlations, further studies are needed. |
format | Online Article Text |
id | pubmed-4607693 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-46076932015-10-29 Delta hepatitis-related thyroid disease: a unique phenomenon Suvak, Burak Dulger, Ahmet Cumhur Aykaç, Mehmet Coskun Gonullu, Hayriye Gonullu, Edip Prz Gastroenterol Original Paper INTRODUCTION: Hepatitis delta virus (HDV) infection is a serious health problem worldwide. Thyroid disturbances represent a major limitation to the efficacy of interferon treatment targeting chronic HDV (C-HDV) infection. Moreover, pre-treatment thyroid diseases may be influenced by interferon therapy. Despite this, the characteristic features of the thyroid diseases in C-HDV patients remain poorly characterised. AIM: To determine the prevalence of thyroid diseases and evaluate the impact of delta hepatitis on thyroid function tests. MATERIAL AND METHODS: We retrospectively reviewed the charts of 127 hepatitis C virus (HCV)-negative adults, treatment-naive outpatients with C-HDV, between July 2013 and July 2014. Thyroid-stimulating hormone (TSH) and thyroid antibodies (TAbs) including anti-thyroid peroxidase antibodies (anti-TPO), liver transaminases, and other routine laboratory tests were conducted during the study period. RESULTS: A total of 127 C-HDV patients (female 52.9%, mean age 54.5 ±8.01 years) were enrolled. The rate of hypothyroidism, defined as a TSH level above 10 IU/l, was 4.7%. No patient had hyperthyroidism. Both elevated levels of liver transaminases and HDV ribonucleic acid (HDV-RNA) were positively correlated with high levels of thyroid autoantibodies. CONCLUSIONS: The rate of hypothyroidism is higher than the rate of hyperthyroidism at baseline. Most remarkably, for the first time we discovered a correlation between disturbed thyroid autoantibodies and elevated liver transaminases as well as high HDV-RNA levels even in euthyroid delta hepatitis patients. But in order to have an adequate understanding of such correlations, further studies are needed. Termedia Publishing House 2015-03-10 2015 /pmc/articles/PMC4607693/ /pubmed/26516384 http://dx.doi.org/10.5114/pg.2015.49687 Text en Copyright © 2015 Termedia http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Paper Suvak, Burak Dulger, Ahmet Cumhur Aykaç, Mehmet Coskun Gonullu, Hayriye Gonullu, Edip Delta hepatitis-related thyroid disease: a unique phenomenon |
title | Delta hepatitis-related thyroid disease: a unique phenomenon |
title_full | Delta hepatitis-related thyroid disease: a unique phenomenon |
title_fullStr | Delta hepatitis-related thyroid disease: a unique phenomenon |
title_full_unstemmed | Delta hepatitis-related thyroid disease: a unique phenomenon |
title_short | Delta hepatitis-related thyroid disease: a unique phenomenon |
title_sort | delta hepatitis-related thyroid disease: a unique phenomenon |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607693/ https://www.ncbi.nlm.nih.gov/pubmed/26516384 http://dx.doi.org/10.5114/pg.2015.49687 |
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