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Do different spectral domain OCT hardwares measure the same? Comparison of retinal thickness using third-party software

PURPOSE: Spectral-domain optical coherence tomographies (OCTs) from different companies do not give identical retinal thicknesses. The purpose of this study was to evaluate if differences in thickness when using a spectral domain Cirrus OCT or a Heidelberg Spectralis are due to hardware differences,...

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Autores principales: Sander, Birgit, Al-Abiji, Hajer Ahmad, Kofod, Mads, Jørgensen, Thomas Martini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607708/
https://www.ncbi.nlm.nih.gov/pubmed/26067394
http://dx.doi.org/10.1007/s00417-015-3075-2
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author Sander, Birgit
Al-Abiji, Hajer Ahmad
Kofod, Mads
Jørgensen, Thomas Martini
author_facet Sander, Birgit
Al-Abiji, Hajer Ahmad
Kofod, Mads
Jørgensen, Thomas Martini
author_sort Sander, Birgit
collection PubMed
description PURPOSE: Spectral-domain optical coherence tomographies (OCTs) from different companies do not give identical retinal thicknesses. The purpose of this study was to evaluate if differences in thickness when using a spectral domain Cirrus OCT or a Heidelberg Spectralis are due to hardware differences, or if they are caused by the segmentation algorithms. METHODS: Thirty-seven healthy eyes were examined within the same session with a Cirrus OCT and a Spectralis OCT, the latter using averaged B-scans. Scans from similar positions and passing the fovea were analyzed by custom-made software. Thickness was analyzed at the fovea, the central 1-mm line and the 6-mm line. RESULTS: When Cirrus and Spectralis scans were analyzed with the same software, the retinal thickness at the foveal center was 225.92 μm (SD 17.0) using the Cirrus and 228.70 μm (SD 18.4) using the Spectralis; the difference of 2.78 μm was not significant (p = 0.055). For the central 1 mm, the difference was 1.78 μm (p = 0.0414), and for all points out to 6 mm, the Spectralis retinal thickness was also significantly larger than the Cirrus thickness (p = 0.0052), though the mean difference was only 1.85 μm. Also for the RPE_OS(complex), Spectralis measured a greater thickness than did Cirrus, with a mean of 3.32 μm (p < 0.0001) for all points. CONCLUSION: The retinal thicknesses from the Cirrus and from the Spectralis differed by 14 μm with the standard software of the instruments, and by less than 3 μm when analyzed with the same custom-made software, indicating that the major differences between the two SD-OCT systems are due to differences in their built-in software algorithms.
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spelling pubmed-46077082015-10-20 Do different spectral domain OCT hardwares measure the same? Comparison of retinal thickness using third-party software Sander, Birgit Al-Abiji, Hajer Ahmad Kofod, Mads Jørgensen, Thomas Martini Graefes Arch Clin Exp Ophthalmol Basic Science PURPOSE: Spectral-domain optical coherence tomographies (OCTs) from different companies do not give identical retinal thicknesses. The purpose of this study was to evaluate if differences in thickness when using a spectral domain Cirrus OCT or a Heidelberg Spectralis are due to hardware differences, or if they are caused by the segmentation algorithms. METHODS: Thirty-seven healthy eyes were examined within the same session with a Cirrus OCT and a Spectralis OCT, the latter using averaged B-scans. Scans from similar positions and passing the fovea were analyzed by custom-made software. Thickness was analyzed at the fovea, the central 1-mm line and the 6-mm line. RESULTS: When Cirrus and Spectralis scans were analyzed with the same software, the retinal thickness at the foveal center was 225.92 μm (SD 17.0) using the Cirrus and 228.70 μm (SD 18.4) using the Spectralis; the difference of 2.78 μm was not significant (p = 0.055). For the central 1 mm, the difference was 1.78 μm (p = 0.0414), and for all points out to 6 mm, the Spectralis retinal thickness was also significantly larger than the Cirrus thickness (p = 0.0052), though the mean difference was only 1.85 μm. Also for the RPE_OS(complex), Spectralis measured a greater thickness than did Cirrus, with a mean of 3.32 μm (p < 0.0001) for all points. CONCLUSION: The retinal thicknesses from the Cirrus and from the Spectralis differed by 14 μm with the standard software of the instruments, and by less than 3 μm when analyzed with the same custom-made software, indicating that the major differences between the two SD-OCT systems are due to differences in their built-in software algorithms. Springer Berlin Heidelberg 2015-06-12 2015 /pmc/articles/PMC4607708/ /pubmed/26067394 http://dx.doi.org/10.1007/s00417-015-3075-2 Text en © The Author(s) 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Basic Science
Sander, Birgit
Al-Abiji, Hajer Ahmad
Kofod, Mads
Jørgensen, Thomas Martini
Do different spectral domain OCT hardwares measure the same? Comparison of retinal thickness using third-party software
title Do different spectral domain OCT hardwares measure the same? Comparison of retinal thickness using third-party software
title_full Do different spectral domain OCT hardwares measure the same? Comparison of retinal thickness using third-party software
title_fullStr Do different spectral domain OCT hardwares measure the same? Comparison of retinal thickness using third-party software
title_full_unstemmed Do different spectral domain OCT hardwares measure the same? Comparison of retinal thickness using third-party software
title_short Do different spectral domain OCT hardwares measure the same? Comparison of retinal thickness using third-party software
title_sort do different spectral domain oct hardwares measure the same? comparison of retinal thickness using third-party software
topic Basic Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607708/
https://www.ncbi.nlm.nih.gov/pubmed/26067394
http://dx.doi.org/10.1007/s00417-015-3075-2
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