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Developmental role of acetylcholinesterase in impulse control in zebrafish
Cellular and molecular processes that mediate individual variability in impulsivity, a key behavioral component of many neuropsychiatric disorders, are poorly understood. Zebrafish heterozygous for a nonsense mutation in ache (ache(sb55/+)) showed lower levels of impulsivity in a 5-choice serial rea...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607786/ https://www.ncbi.nlm.nih.gov/pubmed/26528153 http://dx.doi.org/10.3389/fnbeh.2015.00271 |
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author | Parker, Matthew O. Brock, Alistair J. Sudwarts, Ari Teh, Muy-Teck Combe, Fraser J. Brennan, Caroline H. |
author_facet | Parker, Matthew O. Brock, Alistair J. Sudwarts, Ari Teh, Muy-Teck Combe, Fraser J. Brennan, Caroline H. |
author_sort | Parker, Matthew O. |
collection | PubMed |
description | Cellular and molecular processes that mediate individual variability in impulsivity, a key behavioral component of many neuropsychiatric disorders, are poorly understood. Zebrafish heterozygous for a nonsense mutation in ache (ache(sb55/+)) showed lower levels of impulsivity in a 5-choice serial reaction time task (5-CSRTT) than wild type and ache(+∕+). Assessment of expression of cholinergic (nAChR), serotonergic (5-HT), and dopamine (DR) receptor mRNA in both adult and larval (9 dpf) ache(sb55/+) revealed significant downregulation of chrna2, chrna5, and drd2 mRNA in ache(sb55/+) larvae, but no differences in adults. Acute exposure to cholinergic agonist/antagonists had no effect on impulsivity, supporting the hypothesis that behavioral effects observed in adults were due to lasting impact of developmental alterations in cholinergic and dopaminergic signaling. This shows the cross-species role of cholinergic signaling during brain development in impulsivity, and suggests zebrafish may be a useful model for the role of cholinergic pathways as a target for therapeutic advances in addiction medicine. |
format | Online Article Text |
id | pubmed-4607786 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-46077862015-11-02 Developmental role of acetylcholinesterase in impulse control in zebrafish Parker, Matthew O. Brock, Alistair J. Sudwarts, Ari Teh, Muy-Teck Combe, Fraser J. Brennan, Caroline H. Front Behav Neurosci Neuroscience Cellular and molecular processes that mediate individual variability in impulsivity, a key behavioral component of many neuropsychiatric disorders, are poorly understood. Zebrafish heterozygous for a nonsense mutation in ache (ache(sb55/+)) showed lower levels of impulsivity in a 5-choice serial reaction time task (5-CSRTT) than wild type and ache(+∕+). Assessment of expression of cholinergic (nAChR), serotonergic (5-HT), and dopamine (DR) receptor mRNA in both adult and larval (9 dpf) ache(sb55/+) revealed significant downregulation of chrna2, chrna5, and drd2 mRNA in ache(sb55/+) larvae, but no differences in adults. Acute exposure to cholinergic agonist/antagonists had no effect on impulsivity, supporting the hypothesis that behavioral effects observed in adults were due to lasting impact of developmental alterations in cholinergic and dopaminergic signaling. This shows the cross-species role of cholinergic signaling during brain development in impulsivity, and suggests zebrafish may be a useful model for the role of cholinergic pathways as a target for therapeutic advances in addiction medicine. Frontiers Media S.A. 2015-10-16 /pmc/articles/PMC4607786/ /pubmed/26528153 http://dx.doi.org/10.3389/fnbeh.2015.00271 Text en Copyright © 2015 Parker, Brock, Sudwarts, Teh, Combe and Brennan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Parker, Matthew O. Brock, Alistair J. Sudwarts, Ari Teh, Muy-Teck Combe, Fraser J. Brennan, Caroline H. Developmental role of acetylcholinesterase in impulse control in zebrafish |
title | Developmental role of acetylcholinesterase in impulse control in zebrafish |
title_full | Developmental role of acetylcholinesterase in impulse control in zebrafish |
title_fullStr | Developmental role of acetylcholinesterase in impulse control in zebrafish |
title_full_unstemmed | Developmental role of acetylcholinesterase in impulse control in zebrafish |
title_short | Developmental role of acetylcholinesterase in impulse control in zebrafish |
title_sort | developmental role of acetylcholinesterase in impulse control in zebrafish |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607786/ https://www.ncbi.nlm.nih.gov/pubmed/26528153 http://dx.doi.org/10.3389/fnbeh.2015.00271 |
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