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Opposing Effects of Inhibitors of Aurora-A and EGFR in Autosomal-Dominant Polycystic Kidney Disease

Aurora-A kinase (AURKA) overexpression in numerous tumors induces aneuploidy, in part because of cytokinetic defects. Alisertib and other small-molecule inhibitors targeting AURKA are effective in some patients as monotherapies or combination therapies. Epidermal growth factor receptor (EGFR) pro-pr...

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Detalles Bibliográficos
Autores principales:	Nikonova, Anna S., Deneka, Alexander Y., Eckman, Louisa, Kopp, Meghan C., Hensley, Harvey H., Egleston, Brian L., Golemis, Erica A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2015
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607875/ https://www.ncbi.nlm.nih.gov/pubmed/26528438 http://dx.doi.org/10.3389/fonc.2015.00228

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