The identification of novel Mycobacterium tuberculosis DHFR inhibitors and the investigation of their binding preferences by using molecular modelling

It is an urgent need to develop new drugs for Mycobacterium tuberculosis (Mtb), and the enzyme, dihydrofolate reductase (DHFR) is a recognised drug target. The crystal structures of methotrexate binding to mt- and h-DHFR separately indicate that the glycerol (GOL) binding site is likely to be critic...

Descripción completa

Detalles Bibliográficos
Autores principales: Hong, Wei, Wang, Yu, Chang, Zhe, Yang, Yanhui, Pu, Jing, Sun, Tao, Kaur, Sargit, Sacchettini, James C., Jung, Hunmin, Lin Wong, Wee, Fah Yap, Lee, Fong Ngeow, Yun, Paterson, Ian C., Wang, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607890/
https://www.ncbi.nlm.nih.gov/pubmed/26471125
http://dx.doi.org/10.1038/srep15328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607890/
https://www.ncbi.nlm.nih.gov/pubmed/26471125
http://dx.doi.org/10.1038/srep15328

Ejemplares similares