Polymorphisms in Protamine 1 and Protamine 2 predict the risk of male infertility: a meta-analysis

Several studies have investigated the association between polymorphisms in protamine 1 and 2 genes and male infertility risk, with inconsistent results to date. This meta-analysis based on the 13 published case-control studies, including 7350 cases and 6167 controls, was performed to further establi...

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Autores principales: Jiang, Weijun, Sun, Hui, Zhang, Jing, Zhou, Qing, Wu, Qiuyue, Li, Tianfu, Zhang, Cui, Li, Weiwei, Zhang, Mingchao, Xia, Xinyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607923/
https://www.ncbi.nlm.nih.gov/pubmed/26472740
http://dx.doi.org/10.1038/srep15300
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author Jiang, Weijun
Sun, Hui
Zhang, Jing
Zhou, Qing
Wu, Qiuyue
Li, Tianfu
Zhang, Cui
Li, Weiwei
Zhang, Mingchao
Xia, Xinyi
author_facet Jiang, Weijun
Sun, Hui
Zhang, Jing
Zhou, Qing
Wu, Qiuyue
Li, Tianfu
Zhang, Cui
Li, Weiwei
Zhang, Mingchao
Xia, Xinyi
author_sort Jiang, Weijun
collection PubMed
description Several studies have investigated the association between polymorphisms in protamine 1 and 2 genes and male infertility risk, with inconsistent results to date. This meta-analysis based on the 13 published case-control studies, including 7350 cases and 6167 controls, was performed to further establish the potential association between the 6 common single nucleotide polymorphisms (rs35576928, rs737008, rs35262993, rs2301365, rs1646022, rs2070923) in protamines 1 and 2 and male infertility. The -190C > A (rs2301365) polymorphism was identified as a risk factor for male infertility under all models. Interestingly, rs1646022 and rs737008 polymorphisms exerted protective effects against male sterility in Asian and population-based under some models. No associations between the remaining SNPs and male sterility were observed.
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spelling pubmed-46079232015-10-28 Polymorphisms in Protamine 1 and Protamine 2 predict the risk of male infertility: a meta-analysis Jiang, Weijun Sun, Hui Zhang, Jing Zhou, Qing Wu, Qiuyue Li, Tianfu Zhang, Cui Li, Weiwei Zhang, Mingchao Xia, Xinyi Sci Rep Article Several studies have investigated the association between polymorphisms in protamine 1 and 2 genes and male infertility risk, with inconsistent results to date. This meta-analysis based on the 13 published case-control studies, including 7350 cases and 6167 controls, was performed to further establish the potential association between the 6 common single nucleotide polymorphisms (rs35576928, rs737008, rs35262993, rs2301365, rs1646022, rs2070923) in protamines 1 and 2 and male infertility. The -190C > A (rs2301365) polymorphism was identified as a risk factor for male infertility under all models. Interestingly, rs1646022 and rs737008 polymorphisms exerted protective effects against male sterility in Asian and population-based under some models. No associations between the remaining SNPs and male sterility were observed. Nature Publishing Group 2015-10-16 /pmc/articles/PMC4607923/ /pubmed/26472740 http://dx.doi.org/10.1038/srep15300 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Jiang, Weijun
Sun, Hui
Zhang, Jing
Zhou, Qing
Wu, Qiuyue
Li, Tianfu
Zhang, Cui
Li, Weiwei
Zhang, Mingchao
Xia, Xinyi
Polymorphisms in Protamine 1 and Protamine 2 predict the risk of male infertility: a meta-analysis
title Polymorphisms in Protamine 1 and Protamine 2 predict the risk of male infertility: a meta-analysis
title_full Polymorphisms in Protamine 1 and Protamine 2 predict the risk of male infertility: a meta-analysis
title_fullStr Polymorphisms in Protamine 1 and Protamine 2 predict the risk of male infertility: a meta-analysis
title_full_unstemmed Polymorphisms in Protamine 1 and Protamine 2 predict the risk of male infertility: a meta-analysis
title_short Polymorphisms in Protamine 1 and Protamine 2 predict the risk of male infertility: a meta-analysis
title_sort polymorphisms in protamine 1 and protamine 2 predict the risk of male infertility: a meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607923/
https://www.ncbi.nlm.nih.gov/pubmed/26472740
http://dx.doi.org/10.1038/srep15300
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