Manganese-Mediated Coupling Reaction of Vinylarenes and Aliphatic Alcohols

Alcohols and alkenes are the most abundant and commonly used organic building blocks in the large-scale chemical synthesis. Herein, this is the first time to report a novel and operationally simple coupling reaction of vinylarenes and aliphatic alcohols catalyzed by manganese in the presence of TBHP...

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Autores principales: Zhang, Wei, Wang, Nai-Xing, Bai, Cui-Bing, Wang, Yan-Jing, Lan, Xing-Wang, Xing, Yalan, Li, Yi-He, Wen, Jia-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607950/
https://www.ncbi.nlm.nih.gov/pubmed/26470633
http://dx.doi.org/10.1038/srep15250
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author Zhang, Wei
Wang, Nai-Xing
Bai, Cui-Bing
Wang, Yan-Jing
Lan, Xing-Wang
Xing, Yalan
Li, Yi-He
Wen, Jia-Long
author_facet Zhang, Wei
Wang, Nai-Xing
Bai, Cui-Bing
Wang, Yan-Jing
Lan, Xing-Wang
Xing, Yalan
Li, Yi-He
Wen, Jia-Long
author_sort Zhang, Wei
collection PubMed
description Alcohols and alkenes are the most abundant and commonly used organic building blocks in the large-scale chemical synthesis. Herein, this is the first time to report a novel and operationally simple coupling reaction of vinylarenes and aliphatic alcohols catalyzed by manganese in the presence of TBHP (tert-butyl hydroperoxide). This coupling reaction provides the oxyalkylated products of vinylarenes with good regioselectivity and accomplishes with the principles of step-economies. A possible reaction mechanism has also been proposed.
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spelling pubmed-46079502015-10-28 Manganese-Mediated Coupling Reaction of Vinylarenes and Aliphatic Alcohols Zhang, Wei Wang, Nai-Xing Bai, Cui-Bing Wang, Yan-Jing Lan, Xing-Wang Xing, Yalan Li, Yi-He Wen, Jia-Long Sci Rep Article Alcohols and alkenes are the most abundant and commonly used organic building blocks in the large-scale chemical synthesis. Herein, this is the first time to report a novel and operationally simple coupling reaction of vinylarenes and aliphatic alcohols catalyzed by manganese in the presence of TBHP (tert-butyl hydroperoxide). This coupling reaction provides the oxyalkylated products of vinylarenes with good regioselectivity and accomplishes with the principles of step-economies. A possible reaction mechanism has also been proposed. Nature Publishing Group 2015-10-16 /pmc/articles/PMC4607950/ /pubmed/26470633 http://dx.doi.org/10.1038/srep15250 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zhang, Wei
Wang, Nai-Xing
Bai, Cui-Bing
Wang, Yan-Jing
Lan, Xing-Wang
Xing, Yalan
Li, Yi-He
Wen, Jia-Long
Manganese-Mediated Coupling Reaction of Vinylarenes and Aliphatic Alcohols
title Manganese-Mediated Coupling Reaction of Vinylarenes and Aliphatic Alcohols
title_full Manganese-Mediated Coupling Reaction of Vinylarenes and Aliphatic Alcohols
title_fullStr Manganese-Mediated Coupling Reaction of Vinylarenes and Aliphatic Alcohols
title_full_unstemmed Manganese-Mediated Coupling Reaction of Vinylarenes and Aliphatic Alcohols
title_short Manganese-Mediated Coupling Reaction of Vinylarenes and Aliphatic Alcohols
title_sort manganese-mediated coupling reaction of vinylarenes and aliphatic alcohols
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607950/
https://www.ncbi.nlm.nih.gov/pubmed/26470633
http://dx.doi.org/10.1038/srep15250
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