Alloreactive CD154-expressing T-cell subsets with differential sensitivity to the immunosuppressant, belatacept: potential targets of novel belatacept-based regimens

Belatacept blocks CD28-mediated T-cell costimulation and prevents renal transplant rejection. Understanding T-cell subset sensitivity to belatacept may identify cellular markers for immunosuppression failure to better guide treatment selection. Here, we evaluate the belatacept sensitivity of allo-an...

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Detalles Bibliográficos
Autores principales: Ashokkumar, Chethan, Ganguly, Bishu, Townsend, Robert, White, Jaimie, Levy, Samantha, Moritz, Michael, Mazariegos, George, Sun, Qing, Sindhi, Rakesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607954/
https://www.ncbi.nlm.nih.gov/pubmed/26472085
http://dx.doi.org/10.1038/srep15218

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