Cargando…

Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner

INTRODUCTION: Although caspase-8 is a well-established initiator of apoptosis and suppressor of necroptosis, recent evidence suggests that this enzyme maintains functions beyond its role in cell death. As cells of the innate immune system, and in particular macrophages, are now at the forefront of a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cuda, Carla M., Misharin, Alexander V., Khare, Sonal, Saber, Rana, Tsai, FuNien, Archer, Amy M., Homan, Philip J., Haines, G. Kenneth, Hutcheson, Jack, Dorfleutner, Andrea, Budinger, G. R. Scott, Stehlik, Christian, Perlman, Harris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608154/ https://www.ncbi.nlm.nih.gov/pubmed/26471282 http://dx.doi.org/10.1186/s13075-015-0794-z

Ejemplares similares

Bim suppresses the development of SLE by limiting myeloid inflammatory responses
por: Tsai, FuNien, et al.
Publicado: (2017)

ApoE deficiency exacerbates the development and sustainment of a semi-chronic K/BxN serum transfer-induced arthritis model
por: Archer, Amy M., et al.
Publicado: (2016)

The heterogeneity of lung macrophages in the susceptibility to disease
por: Morales-Nebreda, Luisa, et al.
Publicado: (2015)

The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation
por: Ratsimandresy, Rojo A., et al.
Publicado: (2017)

The caspase-8/RIPK3 signaling axis in antigen presenting cells controls the inflammatory arthritic response
por: Dominguez, Salina, et al.
Publicado: (2017)

The PYRIN domain-only protein POP3 inhibits AIM2-like receptor inflammasomes and regulates responses to DNA virus infections
por: Khare, Sonal, et al.
Publicado: (2014)

RIPK1 blocks T cell senescence mediated by RIPK3 and caspase-8
por: Imanishi, Takayuki, et al.
Publicado: (2023)

Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes
por: Bryan, Nicole B, et al.
Publicado: (2010)

NLRP3 licenses NLRP11 for inflammasome activation in human macrophages
por: Gangopadhyay, Anu, et al.
Publicado: (2022)

The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages
por: Chu, Lan H., et al.
Publicado: (2018)

Macrophage-derived interleukin-6 is necessary and sufficient for choroidal angiogenesis
por: Droho, Steven, et al.
Publicado: (2021)

Impaired Clearance of Influenza A Virus in Obese, Leptin Receptor Deficient Mice Is Independent of Leptin Signaling in the Lung Epithelium and Macrophages
por: Radigan, Kathryn A., et al.
Publicado: (2014)

CD11c(+) macrophages are proangiogenic and necessary for experimental choroidal neovascularization
por: Droho, Steven, et al.
Publicado: (2023)

Monocyte-Derived Macrophages Are Necessary for Beta-Adrenergic Receptor-Driven Choroidal Neovascularization Inhibition
por: Droho, Steven, et al.
Publicado: (2019)

RIPK1 and RIPK3 regulate TNFα-induced β-cell death in concert with caspase activity
por: Contreras, Christopher J., et al.
Publicado: (2022)

An Update on CARD Only Proteins (COPs) and PYD Only Proteins (POPs) as Inflammasome Regulators
por: Devi, Savita, et al.
Publicado: (2020)

A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signalling in monocyte-derived alveolar macrophages
por: Joshi, Nikita, et al.
Publicado: (2020)

Bcl-x(L) mediates RIPK3-dependent necrosis in M. tuberculosis-infected macrophages
por: Zhao, Xiaomin, et al.
Publicado: (2017)

An Update on PYRIN Domain-Containing Pattern Recognition Receptors: From Immunity to Pathology
por: Ratsimandresy, Rojo A., et al.
Publicado: (2013)

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease
por: Lalaoui, Najoua, et al.
Publicado: (2019)

RIPK3 and caspase 8 collaborate to limit herpes simplex encephalitis
por: Guo, Hongyan, et al.
Publicado: (2022)

Caspase-8 deficiency in mouse embryos triggers chronic RIPK1-dependent activation of inflammatory genes, independently of RIPK3
por: Kang, Tae-Bong, et al.
Publicado: (2018)

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span
por: Misharin, Alexander V., et al.
Publicado: (2017)

Ocular macrophage origin and heterogeneity during steady state and experimental choroidal neovascularization
por: Droho, Steven, et al.
Publicado: (2020)

RIPK1 suppresses apoptosis mediated by TNF and caspase-3 in intervertebral discs
por: Qiu, Xubin, et al.
Publicado: (2019)

Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation
por: Speir, Mary, et al.
Publicado: (2019)

Role of RIPK1 in SMAC mimetics-induced apoptosis in primary human HIV-infected macrophages
por: Caballero, Ramon Edwin, et al.
Publicado: (2021)

The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway
por: Ratsimandresy, Rojo A, et al.
Publicado: (2017)

Caspase-8, receptor-interacting protein kinase 1 (RIPK1), and RIPK3 regulate retinoic acid-induced cell differentiation and necroptosis
por: Someda, Masataka, et al.
Publicado: (2019)

Reprogramming monocyte-derived macrophages through caspase inhibition
por: Chaintreuil, Paul, et al.
Publicado: (2021)

Caspase inhibition prolongs inflammation by promoting a signaling complex with activated RIPK1
por: Huang, Xinyue, et al.
Publicado: (2021)

Caspase‐11 counteracts mitochondrial ROS‐mediated clearance of Staphylococcus aureus in macrophages
por: Krause, Kathrin, et al.
Publicado: (2019)

Card9 protects sepsis by regulating Ripk2-mediated activation of NLRP3 inflammasome in macrophages
por: Xu, Zhen, et al.
Publicado: (2022)

Chlamydia muridarum Infection of Macrophages Stimulates IL-1β Secretion and Cell Death via Activation of Caspase-1 in an RIP3-Independent Manner
por: Chen, Lixiang, et al.
Publicado: (2017)

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis
por: Oberst, Andrew, et al.
Publicado: (2011)

Human Rhinovirus 3C protease cleaves RIPK1, concurrent with caspase 8 activation
por: Croft, Sarah N., et al.
Publicado: (2018)

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation
por: Liccardi, Gianmaria, et al.
Publicado: (2019)

Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation
por: Wang, Yaqiu, et al.
Publicado: (2022)

Macrophages migrate in an activation-dependent manner to chemokines involved in neuroinflammation
por: Vogel, Daphne YS, et al.
Publicado: (2014)

Flagellin attenuates experimental sepsis in a macrophage-dependent manner
por: Yang, Xiaoliang, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_t3dv1a85aaqclm9rdlj7ae88cc