Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology

The multigram-scale synthesis of a sulfation-site programmed heparin-like dodecasaccharide is described. Evaluation alongside dodecasaccharides lacking this single glucosamine O6-sulfation, or having per-O6-sulfation, shows that site-specific modification of the terminal glucosamine dramatically int...

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Detalles Bibliográficos
Autores principales: Jayson, Gordon C., Hansen, Steen U., Miller, Gavin J., Cole, Claire L., Rushton, Graham, Avizienyte, Egle, Gardiner, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608306/
https://www.ncbi.nlm.nih.gov/pubmed/26234943
http://dx.doi.org/10.1039/c5cc05222j
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author Jayson, Gordon C.
Hansen, Steen U.
Miller, Gavin J.
Cole, Claire L.
Rushton, Graham
Avizienyte, Egle
Gardiner, John M.
author_facet Jayson, Gordon C.
Hansen, Steen U.
Miller, Gavin J.
Cole, Claire L.
Rushton, Graham
Avizienyte, Egle
Gardiner, John M.
author_sort Jayson, Gordon C.
collection PubMed
description The multigram-scale synthesis of a sulfation-site programmed heparin-like dodecasaccharide is described. Evaluation alongside dodecasaccharides lacking this single glucosamine O6-sulfation, or having per-O6-sulfation, shows that site-specific modification of the terminal glucosamine dramatically interconverts regulation of in vitro and in vivo biology mediated by the two important chemokines, CXCL12 (SDF1α) or CXCL8 (IL-8).
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spelling pubmed-46083062015-11-05 Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology Jayson, Gordon C. Hansen, Steen U. Miller, Gavin J. Cole, Claire L. Rushton, Graham Avizienyte, Egle Gardiner, John M. Chem Commun (Camb) Chemistry The multigram-scale synthesis of a sulfation-site programmed heparin-like dodecasaccharide is described. Evaluation alongside dodecasaccharides lacking this single glucosamine O6-sulfation, or having per-O6-sulfation, shows that site-specific modification of the terminal glucosamine dramatically interconverts regulation of in vitro and in vivo biology mediated by the two important chemokines, CXCL12 (SDF1α) or CXCL8 (IL-8). Royal Society of Chemistry 2015-09-18 2015-08-03 /pmc/articles/PMC4608306/ /pubmed/26234943 http://dx.doi.org/10.1039/c5cc05222j Text en This journal is © The Royal Society of Chemistry 2015 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Jayson, Gordon C.
Hansen, Steen U.
Miller, Gavin J.
Cole, Claire L.
Rushton, Graham
Avizienyte, Egle
Gardiner, John M.
Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology
title Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology
title_full Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology
title_fullStr Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology
title_full_unstemmed Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology
title_short Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology
title_sort synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts cxcl8 and cxcl12 chemokine biology
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608306/
https://www.ncbi.nlm.nih.gov/pubmed/26234943
http://dx.doi.org/10.1039/c5cc05222j
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