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Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology

The multigram-scale synthesis of a sulfation-site programmed heparin-like dodecasaccharide is described. Evaluation alongside dodecasaccharides lacking this single glucosamine O6-sulfation, or having per-O6-sulfation, shows that site-specific modification of the terminal glucosamine dramatically int...

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Detalles Bibliográficos
Autores principales:	Jayson, Gordon C., Hansen, Steen U., Miller, Gavin J., Cole, Claire L., Rushton, Graham, Avizienyte, Egle, Gardiner, John M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2015
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608306/ https://www.ncbi.nlm.nih.gov/pubmed/26234943 http://dx.doi.org/10.1039/c5cc05222j

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