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Systematic review of the impact of feed protein type and degree of hydrolysis on gastric emptying in children

BACKGROUND: The choice of infant formula is thought to play an important role on gastric emptying (GE) in a variety of gastrointestinal disorders. It is known that many ingredients impact on GE, including the type of protein and level of hydrolysis. In clinical practice, feeds are often recommended...

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Autores principales: Meyer, Rosan, Foong, Ru-Xin Melanie, Thapar, Nikhil, Kritas, Stamatiki, Shah, Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608328/
https://www.ncbi.nlm.nih.gov/pubmed/26472544
http://dx.doi.org/10.1186/s12876-015-0369-0
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author Meyer, Rosan
Foong, Ru-Xin Melanie
Thapar, Nikhil
Kritas, Stamatiki
Shah, Neil
author_facet Meyer, Rosan
Foong, Ru-Xin Melanie
Thapar, Nikhil
Kritas, Stamatiki
Shah, Neil
author_sort Meyer, Rosan
collection PubMed
description BACKGROUND: The choice of infant formula is thought to play an important role on gastric emptying (GE) in a variety of gastrointestinal disorders. It is known that many ingredients impact on GE, including the type of protein and level of hydrolysis. In clinical practice, feeds are often recommended due to putative improved GE related to the type of protein and level of hydrolysis, however whether this is scientifically justified still needs to be established. A systematic review comparing the impact of protein type and hydrolysis on GE in children was therefore performed. METHODS: The Patient, Intervention, Comparison and Outcome system was used. A structured literature search was performed using the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines, searching PubMed, Cochrane databases and Google Scholar from 1990 to 2014. We only included articles published in full text English language using specific search terms, including both scintigraphy and C13-octanoic acid breath test. RESULTS: We identified 126 publications of which 20 were eligible for inclusion but only 8 were included. Studies reviewed GE in both healthy children as well as those with neurodevelopmental delay and reflux. Two studies investigating GE of breast milk versus formula indicated a faster GE for breast milk. Four studies found that feeds containing whole whey in varying amounts emptied faster than predominant whole casein feeds and one study found no difference in GE. Five studies investigated a mix of whole versus hydrolysed protein and found conflicting results related to study population and hydrolysis. CONCLUSIONS: Breast milk has a faster GE than formula milk. Although there seems to be a trend towards whey feeds emptying faster, different methodologies, feed compositions and patient groups makes it difficult to draw firm conclusions. Future studies should be performed with comparable feeds in populations where increased GE may be of clinical benefit.
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spelling pubmed-46083282015-10-17 Systematic review of the impact of feed protein type and degree of hydrolysis on gastric emptying in children Meyer, Rosan Foong, Ru-Xin Melanie Thapar, Nikhil Kritas, Stamatiki Shah, Neil BMC Gastroenterol Research Article BACKGROUND: The choice of infant formula is thought to play an important role on gastric emptying (GE) in a variety of gastrointestinal disorders. It is known that many ingredients impact on GE, including the type of protein and level of hydrolysis. In clinical practice, feeds are often recommended due to putative improved GE related to the type of protein and level of hydrolysis, however whether this is scientifically justified still needs to be established. A systematic review comparing the impact of protein type and hydrolysis on GE in children was therefore performed. METHODS: The Patient, Intervention, Comparison and Outcome system was used. A structured literature search was performed using the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines, searching PubMed, Cochrane databases and Google Scholar from 1990 to 2014. We only included articles published in full text English language using specific search terms, including both scintigraphy and C13-octanoic acid breath test. RESULTS: We identified 126 publications of which 20 were eligible for inclusion but only 8 were included. Studies reviewed GE in both healthy children as well as those with neurodevelopmental delay and reflux. Two studies investigating GE of breast milk versus formula indicated a faster GE for breast milk. Four studies found that feeds containing whole whey in varying amounts emptied faster than predominant whole casein feeds and one study found no difference in GE. Five studies investigated a mix of whole versus hydrolysed protein and found conflicting results related to study population and hydrolysis. CONCLUSIONS: Breast milk has a faster GE than formula milk. Although there seems to be a trend towards whey feeds emptying faster, different methodologies, feed compositions and patient groups makes it difficult to draw firm conclusions. Future studies should be performed with comparable feeds in populations where increased GE may be of clinical benefit. BioMed Central 2015-10-15 /pmc/articles/PMC4608328/ /pubmed/26472544 http://dx.doi.org/10.1186/s12876-015-0369-0 Text en © Meyer et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Meyer, Rosan
Foong, Ru-Xin Melanie
Thapar, Nikhil
Kritas, Stamatiki
Shah, Neil
Systematic review of the impact of feed protein type and degree of hydrolysis on gastric emptying in children
title Systematic review of the impact of feed protein type and degree of hydrolysis on gastric emptying in children
title_full Systematic review of the impact of feed protein type and degree of hydrolysis on gastric emptying in children
title_fullStr Systematic review of the impact of feed protein type and degree of hydrolysis on gastric emptying in children
title_full_unstemmed Systematic review of the impact of feed protein type and degree of hydrolysis on gastric emptying in children
title_short Systematic review of the impact of feed protein type and degree of hydrolysis on gastric emptying in children
title_sort systematic review of the impact of feed protein type and degree of hydrolysis on gastric emptying in children
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608328/
https://www.ncbi.nlm.nih.gov/pubmed/26472544
http://dx.doi.org/10.1186/s12876-015-0369-0
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