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STAT3-mediated IGF-2 secretion in the tumour microenvironment elicits innate resistance to anti-IGF-1R antibody

Drug resistance is a major impediment in medical oncology. Recent studies have emphasized the importance of the tumour microenvironment (TME) to innate resistance, to molecularly targeted therapies. In this study, we investigate the role of TME in resistance to cixutumumab, an anti-IGF-1R monoclonal...

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Detalles Bibliográficos
Autores principales:	Lee, Ji-Sun, Kang, Ju-Hee, Boo, Hye-Jin, Hwang, Su-Jung, Hong, Sungyoul, Lee, Su-Chan, Park, Young-Jun, Chung, Tae-Moon, Youn, Hyewon, Mi Lee, Seung, Jae Kim, Byoung, Chung, June-Key, Chung, Yeonseok, William, William N., Kee Shin, Young, Lee, Hyo-Jong, Oh, Seung-Hyun, Lee, Ho-Young
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608384/ https://www.ncbi.nlm.nih.gov/pubmed/26465273 http://dx.doi.org/10.1038/ncomms9499

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