Cargando…

Digital signaling decouples activation probability and population heterogeneity

Digital signaling enhances robustness of cellular decisions in noisy environments, but it is unclear how digital systems transmit temporal information about a stimulus. To understand how temporal input information is encoded and decoded by the NF-κB system, we studied transcription factor dynamics a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kellogg, Ryan A, Tian, Chengzhe, Lipniacki, Tomasz, Quake, Stephen R, Tay, Savaş
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2015
Materias:	Computational and Systems Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608393/ https://www.ncbi.nlm.nih.gov/pubmed/26488364 http://dx.doi.org/10.7554/eLife.08931

Ejemplares similares

HSV-1 single-cell analysis reveals the activation of anti-viral and developmental programs in distinct sub-populations
por: Drayman, Nir, et al.
Publicado: (2019)

Decoupling kinematics and mechanics reveals coding properties of trigeminal ganglion neurons in the rat vibrissal system
por: Bush, Nicholas E, et al.
Publicado: (2016)

Ecological feedback in quorum-sensing microbial populations can induce heterogeneous production of autoinducers
por: Bauer, Matthias, et al.
Publicado: (2017)

Self-assembling manifolds in single-cell RNA sequencing data
por: Tarashansky, Alexander J, et al.
Publicado: (2019)

Heterogeneous absorption of antimicrobial peptide LL37 in Escherichia coli cells enhances population survivability
por: Snoussi, Mehdi, et al.
Publicado: (2018)

Spontaneous NF-κB Activation by Autocrine TNFα Signaling: A Computational Analysis
por: Pękalski, Jakub, et al.
Publicado: (2013)

Probable nature of higher-dimensional symmetries underlying mammalian grid-cell activity patterns
por: Mathis, Alexander, et al.
Publicado: (2015)

Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains
por: Meller, Artur, et al.
Publicado: (2023)

Microfluidic-based mini-metagenomics enables discovery of novel microbial lineages from complex environmental samples
por: Yu, Feiqiao Brian, et al.
Publicado: (2017)

Mapping single-cell atlases throughout Metazoa unravels cell type evolution
por: Tarashansky, Alexander J, et al.
Publicado: (2021)

Lineage tracing of human B cells reveals the in vivo landscape of human antibody class switching
por: Horns, Felix, et al.
Publicado: (2016)

Correction: Lineage tracing of human B cells reveals the in vivo landscape of human antibody class switching
por: Horns, Felix, et al.
Publicado: (2016)

Heterogeneity of the GFP fitness landscape and data-driven protein design
por: Gonzalez Somermeyer, Louisa, et al.
Publicado: (2022)

Dynamics and heterogeneity of a fate determinant during transition towards cell differentiation
por: Peláez, Nicolás, et al.
Publicado: (2015)

Cytotoxic T cells swarm by homotypic chemokine signalling
por: Galeano Niño, Jorge Luis, et al.
Publicado: (2020)

Single cell RNA-seq identifies the origins of heterogeneity in efficient cell transdifferentiation and reprogramming
por: Francesconi, Mirko, et al.
Publicado: (2019)

Topological signatures in regulatory network enable phenotypic heterogeneity in small cell lung cancer
por: Chauhan, Lakshya, et al.
Publicado: (2021)

RNA splicing programs define tissue compartments and cell types at single-cell resolution
por: Olivieri, Julia Eve, et al.
Publicado: (2021)

An open-source computational and data resource to analyze digital maps of immunopeptidomes
por: Caron, Etienne, et al.
Publicado: (2015)

Memory CD4 T cell subsets are kinetically heterogeneous and replenished from naive T cells at high levels
por: Gossel, Graeme, et al.
Publicado: (2017)

Stochasticity in the miR-9/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation
por: Phillips, Nick E, et al.
Publicado: (2016)

A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning
por: Wang, Qixuan, et al.
Publicado: (2017)

A versatile pipeline for the multi-scale digital reconstruction and quantitative analysis of 3D tissue architecture
por: Morales-Navarrete, Hernán, et al.
Publicado: (2015)

Decoupling Drupal: a decoupled design approach for web applications
por: Mayekar, Deepali
Publicado: (2017)

Predicting ventricular tachycardia circuits in patients with arrhythmogenic right ventricular cardiomyopathy using genotype-specific heart digital twins
por: Zhang, Yingnan, et al.
Publicado: (2023)

Heterogeneous T cell motility behaviors emerge from a coupling between speed and turning in vivo
por: Jerison, Elizabeth R, et al.
Publicado: (2020)

A community-maintained standard library of population genetic models
por: Adrion, Jeffrey R, et al.
Publicado: (2020)

Cis-activation in the Notch signaling pathway
por: Nandagopal, Nagarajan, et al.
Publicado: (2019)

Population adaptation in efficient balanced networks
por: Gutierrez, Gabrielle J, et al.
Publicado: (2019)

Synchronized switching of multiple toxin–antitoxin modules by (p)ppGpp fluctuation
por: Tian, Chengzhe, et al.
Publicado: (2017)

Decoupled Drupal in practice: architect and implement decoupled Drupal architectures across the stack
por: So, Preston, et al.
Publicado: (2018)

Paracrine communication maximizes cellular response fidelity in wound signaling
por: Handly, L Naomi, et al.
Publicado: (2015)

The pattern of nodal morphogen signaling is shaped by co-receptor expression
por: Lord, Nathan D, et al.
Publicado: (2021)

Attention stabilizes the shared gain of V4 populations
por: Rabinowitz, Neil C, et al.
Publicado: (2015)

Antibiotic-induced population fluctuations and stochastic clearance of bacteria
por: Coates, Jessica, et al.
Publicado: (2018)

Dynamic range adaptation in primary motor cortical populations
por: Rasmussen, Robert G, et al.
Publicado: (2017)

Stable task information from an unstable neural population
por: Rule, Michael E, et al.
Publicado: (2020)

Social fluidity mobilizes contagion in human and animal populations
por: Colman, Ewan, et al.
Publicado: (2021)

Tree crickets optimize the acoustics of baffles to exaggerate their mate-attraction signal
por: Mhatre, Natasha, et al.
Publicado: (2017)

Dynamics of BMP signaling and distribution during zebrafish dorsal-ventral patterning
por: Pomreinke, Autumn P, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_tkptkdolebh8cd66m11oddhu6l