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Ventricular Tachycardia and Early Fibrillation in Patients With Brugada Syndrome and Ischemic Cardiomyopathy Show Predictable Frequency-Phase Properties on the Precordial ECG Consistent With the Respective Arrhythmogenic Substrate

Ventricular fibrillation (VF) has been proposed to be maintained by localized high-frequency sources. We tested whether spectral-phase analysis of the precordial ECG enabled identification of periodic activation patterns generated by such sources. METHODS AND RESULTS—: Precordial ECGs were recorded...

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Autores principales: Calvo, David, Atienza, Felipe, Saiz, Javier, Martínez, Laura, Ávila, Pablo, Rubín, José, Herreros, Benito, Arenal, Ángel, García-Fernández, Javier, Ferrer, Ana, Sebastián, Rafael, Martínez-Camblor, Pablo, Jalife, José, Berenfeld, Omer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608487/
https://www.ncbi.nlm.nih.gov/pubmed/26253505
http://dx.doi.org/10.1161/CIRCEP.114.002717
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author Calvo, David
Atienza, Felipe
Saiz, Javier
Martínez, Laura
Ávila, Pablo
Rubín, José
Herreros, Benito
Arenal, Ángel
García-Fernández, Javier
Ferrer, Ana
Sebastián, Rafael
Martínez-Camblor, Pablo
Jalife, José
Berenfeld, Omer
author_facet Calvo, David
Atienza, Felipe
Saiz, Javier
Martínez, Laura
Ávila, Pablo
Rubín, José
Herreros, Benito
Arenal, Ángel
García-Fernández, Javier
Ferrer, Ana
Sebastián, Rafael
Martínez-Camblor, Pablo
Jalife, José
Berenfeld, Omer
author_sort Calvo, David
collection PubMed
description Ventricular fibrillation (VF) has been proposed to be maintained by localized high-frequency sources. We tested whether spectral-phase analysis of the precordial ECG enabled identification of periodic activation patterns generated by such sources. METHODS AND RESULTS—: Precordial ECGs were recorded from 15 ischemic cardiomyopathy and 15 Brugada syndrome (type 1 ECG) patients during induced VF and analyzed in the frequency-phase domain. Despite temporal variability, induced VF episodes lasting 19.6±7.9 s displayed distinctly high power at a common frequency (shared frequency, 5.7±1.1 Hz) in all leads about half of the time. In patients with Brugada syndrome, phase analysis of shared frequency showed a V(1)–V(6) sequence as would be expected from patients displaying a type 1 ECG pattern (P<0.001). Hilbert-based phases confirmed that the most stable sequence over the whole VF duration was V(1)–V(6). Analysis of shared frequency in ischemic cardiomyopathy patients with anteroseptal (n=4), apical (n=3), and inferolateral (n=4) myocardial infarction displayed a sequence starting at V(1)–V(2), V(3)–V(4), and V(5)–V(6), respectively, consistent with an activation origin at the scar location (P=0.005). Sequences correlated with the Hilbert-based phase analysis (P<0.001). Posterior infarction (n=4) displayed no specific sequence. On paired comparison, phase sequences during monomorphic ventricular tachycardia correlated moderately with VF (P<0.001). Moreover, there was a dominant frequency gradient from precordial leads facing the scar region to the contralateral leads (5.8±0.8 versus 5.4±1.1 Hz; P=0.004). CONCLUSIONS—: Noninvasive analysis of ventricular tachycardia and early VF in patients with Brugada syndrome and ischemic cardiomyopathy shows a predictable sequence in the frequency-phase domain, consistent with anatomic location of the arrhythmogenic substrate.
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spelling pubmed-46084872015-11-02 Ventricular Tachycardia and Early Fibrillation in Patients With Brugada Syndrome and Ischemic Cardiomyopathy Show Predictable Frequency-Phase Properties on the Precordial ECG Consistent With the Respective Arrhythmogenic Substrate Calvo, David Atienza, Felipe Saiz, Javier Martínez, Laura Ávila, Pablo Rubín, José Herreros, Benito Arenal, Ángel García-Fernández, Javier Ferrer, Ana Sebastián, Rafael Martínez-Camblor, Pablo Jalife, José Berenfeld, Omer Circ Arrhythm Electrophysiol Original Articles Ventricular fibrillation (VF) has been proposed to be maintained by localized high-frequency sources. We tested whether spectral-phase analysis of the precordial ECG enabled identification of periodic activation patterns generated by such sources. METHODS AND RESULTS—: Precordial ECGs were recorded from 15 ischemic cardiomyopathy and 15 Brugada syndrome (type 1 ECG) patients during induced VF and analyzed in the frequency-phase domain. Despite temporal variability, induced VF episodes lasting 19.6±7.9 s displayed distinctly high power at a common frequency (shared frequency, 5.7±1.1 Hz) in all leads about half of the time. In patients with Brugada syndrome, phase analysis of shared frequency showed a V(1)–V(6) sequence as would be expected from patients displaying a type 1 ECG pattern (P<0.001). Hilbert-based phases confirmed that the most stable sequence over the whole VF duration was V(1)–V(6). Analysis of shared frequency in ischemic cardiomyopathy patients with anteroseptal (n=4), apical (n=3), and inferolateral (n=4) myocardial infarction displayed a sequence starting at V(1)–V(2), V(3)–V(4), and V(5)–V(6), respectively, consistent with an activation origin at the scar location (P=0.005). Sequences correlated with the Hilbert-based phase analysis (P<0.001). Posterior infarction (n=4) displayed no specific sequence. On paired comparison, phase sequences during monomorphic ventricular tachycardia correlated moderately with VF (P<0.001). Moreover, there was a dominant frequency gradient from precordial leads facing the scar region to the contralateral leads (5.8±0.8 versus 5.4±1.1 Hz; P=0.004). CONCLUSIONS—: Noninvasive analysis of ventricular tachycardia and early VF in patients with Brugada syndrome and ischemic cardiomyopathy shows a predictable sequence in the frequency-phase domain, consistent with anatomic location of the arrhythmogenic substrate. Lippincott Williams & Wilkins 2015-10 2015-10-30 /pmc/articles/PMC4608487/ /pubmed/26253505 http://dx.doi.org/10.1161/CIRCEP.114.002717 Text en © 2015 The Authors. Circulation: Arrhythmia and Electrophysiology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDervis (https://creativecommons.org/licenses/by-nc-nd/3.0/) License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.
spellingShingle Original Articles
Calvo, David
Atienza, Felipe
Saiz, Javier
Martínez, Laura
Ávila, Pablo
Rubín, José
Herreros, Benito
Arenal, Ángel
García-Fernández, Javier
Ferrer, Ana
Sebastián, Rafael
Martínez-Camblor, Pablo
Jalife, José
Berenfeld, Omer
Ventricular Tachycardia and Early Fibrillation in Patients With Brugada Syndrome and Ischemic Cardiomyopathy Show Predictable Frequency-Phase Properties on the Precordial ECG Consistent With the Respective Arrhythmogenic Substrate
title Ventricular Tachycardia and Early Fibrillation in Patients With Brugada Syndrome and Ischemic Cardiomyopathy Show Predictable Frequency-Phase Properties on the Precordial ECG Consistent With the Respective Arrhythmogenic Substrate
title_full Ventricular Tachycardia and Early Fibrillation in Patients With Brugada Syndrome and Ischemic Cardiomyopathy Show Predictable Frequency-Phase Properties on the Precordial ECG Consistent With the Respective Arrhythmogenic Substrate
title_fullStr Ventricular Tachycardia and Early Fibrillation in Patients With Brugada Syndrome and Ischemic Cardiomyopathy Show Predictable Frequency-Phase Properties on the Precordial ECG Consistent With the Respective Arrhythmogenic Substrate
title_full_unstemmed Ventricular Tachycardia and Early Fibrillation in Patients With Brugada Syndrome and Ischemic Cardiomyopathy Show Predictable Frequency-Phase Properties on the Precordial ECG Consistent With the Respective Arrhythmogenic Substrate
title_short Ventricular Tachycardia and Early Fibrillation in Patients With Brugada Syndrome and Ischemic Cardiomyopathy Show Predictable Frequency-Phase Properties on the Precordial ECG Consistent With the Respective Arrhythmogenic Substrate
title_sort ventricular tachycardia and early fibrillation in patients with brugada syndrome and ischemic cardiomyopathy show predictable frequency-phase properties on the precordial ecg consistent with the respective arrhythmogenic substrate
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608487/
https://www.ncbi.nlm.nih.gov/pubmed/26253505
http://dx.doi.org/10.1161/CIRCEP.114.002717
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