Cargando…

Aging Impairs the Ability of Conventional Dendritic Cells to Cross-Prime CD8(+) T Cells upon Stimulation with a TLR7 Ligand

The aging process is accompanied by altered immune system functioning and an increased risk of infection. Dendritic cells (DCs) are antigen-presenting cells that play a key role in both adaptive and innate immunity, but how aging affects DCs and their influence on immunity has not been thoroughly es...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zacca, Estefanía R., Crespo, María I., Acland, Rachel P., Roselli, Emiliano, Núñez, Nicolás G., Maccioni, Mariana, Maletto, Belkys A., Pistoresi-Palencia, María C., Morón, Gabriel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608578/ https://www.ncbi.nlm.nih.gov/pubmed/26474053 http://dx.doi.org/10.1371/journal.pone.0140672

Ejemplares similares

Neutrophils Which Migrate to Lymph Nodes Modulate CD4(+) T Cell Response by a PD-L1 Dependent Mechanism
por: Castell, Sofía D., et al.
Publicado: (2019)

Expansion of myeloid-derived suppressor cells with arginase activity lasts longer in aged than in young mice after CpG-ODN plus IFA treatment
por: Harman, María F., et al.
Publicado: (2015)

Class-B CpG-ODN Formulated With a Nanostructure Induces Type I Interferons-Dependent and CD4(+) T Cell-Independent CD8(+) T-Cell Response Against Unconjugated Protein Antigen
por: Chiodetti, Ana L., et al.
Publicado: (2018)

TLR3 Activation of Intratumoral CD103(+) Dendritic Cells Modifies the Tumor Infiltrate Conferring Anti-tumor Immunity
por: Roselli, Emiliano, et al.
Publicado: (2019)

Photodynamic Modulation of Type 1 Interferon Pathway on Melanoma Cells Promotes Dendritic Cell Activation
por: Lamberti, María Julia, et al.
Publicado: (2019)

Signaling through NOD-2 and TLR-4 Bolsters the T cell Priming Capability of Dendritic cells by Inducing Autophagy
por: Khan, Nargis, et al.
Publicado: (2016)

Human Intestinal Dendritic Cells Decrease Cytokine Release against Salmonella Infection in the Presence of Lactobacillus paracasei upon TLR Activation
por: Bermudez-Brito, Miriam, et al.
Publicado: (2012)

Expression of Toll-like receptor (TLR) 2, TLR3, TLR4 and TLR7 is increased in rheumatoid arthritis synovium and regulates cytokine production by dendritic cells upon stimulation of TLR specific pathways
por: Roelofs, MF, et al.
Publicado: (2005)

Fast Maturation of Splenic Dendritic Cells Upon TBI Is Associated With FLT3/FLT3L Signaling
por: Zhang, Jin, et al.
Publicado: (2022)

Immature Dendritic Cells Acquire Cd8(+)Cytotoxic T Lymphocyte Priming Capacity upon Activation by T Helper Cell–Independent or–Dependent Stimuli
por: Schuurhuis, Danita H., et al.
Publicado: (2000)

TLR7/TLR8 Activation Restores Defective Cytokine Secretion by Myeloid Dendritic Cells but Not by Plasmacytoid Dendritic Cells in HIV-Infected Pregnant Women and Newborns
por: Cardoso, Elaine Cristina, et al.
Publicado: (2013)

Mobilizing Dendritic Cells for Tolerance, Priming, and Chronic Inflammation
por: Sallusto, Federica, et al.
Publicado: (1999)

Hybrid LNP Prime Dendritic Cells for Nucleotide Delivery
por: Das, Riddha, et al.
Publicado: (2023)

The combination of TLR2 and TLR4 agonists promotes the immunogenicity of dendritic cell/cancer cell fusions
por: Koido, Shigeo, et al.
Publicado: (2013)

Early Transcriptional Signature in Dendritic Cells and the Induction of Protective T Cell Responses Upon Immunization With VLPs Containing TLR Ligands—A Role for CCL2
por: Gomes, Ariane C., et al.
Publicado: (2019)

L-Myc expression by dendritic cells is required for optimal T-cell priming
por: Wumesh, KC, et al.
Publicado: (2014)

Myocardial Infarction Primes Autoreactive T Cells through Activation of Dendritic Cells
por: Van der Borght, Katrien, et al.
Publicado: (2017)

Phosphatidylinositol 3-kinase interacts with the glucocorticoid receptor upon TLR2 activation
por: Arancibia, Sergio, et al.
Publicado: (2011)

HIV/SIV Infection Primes Monocytes and Dendritic Cells for Apoptosis
por: Laforge, Mireille, et al.
Publicado: (2011)

Ready for Prime Time? Dendritic Cells in High-Grade Gliomas
por: Conarroe, Claire A., et al.
Publicado: (2023)

Plasmacytoid dendritic cells prime IL-10–producing T regulatory cells by inducible costimulator ligand
por: Ito, Tomoki, et al.
Publicado: (2007)

Downregulation of adaptor protein MyD88 compromises the angiogenic potential of B16 murine melanoma
por: Trucco, Lucas Daniel, et al.
Publicado: (2017)

Lipopolysaccharide‐primed heterotolerant dendritic cells suppress experimental autoimmune uveoretinitis by multiple mechanisms
por: Klaska, Izabela P., et al.
Publicado: (2016)

Mouse T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex
por: Blumenthal, Daniel, et al.
Publicado: (2020)

Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement
por: Chieppa, Marcello, et al.
Publicado: (2006)

The Immunomodulatory Effect of Bone-Marrow Mesenchymal Stem Cells on Expression of TLR3 and TLR9 in Mice Dendritic Cells
por: Sadeghi, L., et al.
Publicado: (2017)

Tolerance induced via TLR2 and TLR4 in human dendritic cells: role of IRAK-1
por: Albrecht, Valerie, et al.
Publicado: (2008)

Antigen acquisition by dendritic cells: intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo
Publicado: (1993)

Dendritic Cell Cross-Priming Is Essential for Immune Responses to Listeria monocytogenes
por: Reinicke, Anna T., et al.
Publicado: (2009)

Exploiting the Role of Endogenous Lymphoid-Resident Dendritic Cells in the Priming of NKT Cells and CD8+ T Cells to Dendritic Cell-Based Vaccines
por: Petersen, Troels R., et al.
Publicado: (2011)

Helminth Antigens Enable CpG-Activated Dendritic Cells to Inhibit the Symptoms of Collagen-induced Arthritis through Foxp3+ Regulatory T Cells
por: Carranza, Franco, et al.
Publicado: (2012)

RSC primes the quiescent genome for hypertranscription upon cell-cycle re-entry
por: Cucinotta, Christine E, et al.
Publicado: (2021)

Hyperosmolarity impedes the cross-priming competence of dendritic cells in a TRIF-dependent manner
por: Popovic, Zoran V., et al.
Publicado: (2017)

Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells
por: Stary, Georg, et al.
Publicado: (2007)

The Scavenger Receptor MARCO Modulates TLR-Induced Responses in Dendritic Cells
por: Kissick, Haydn T., et al.
Publicado: (2014)

Immunodominant proteins α-1 giardin and β-giardin are expressed in both assemblages A and B of Giardia lamblia
por: Feliziani, Constanza, et al.
Publicado: (2011)

TLR2 and TLR4 as Potential Biomarkers of Environmental Particulate Matter Exposed Human Myeloid Dendritic Cells
por: Williams, Marc A., et al.
Publicado: (2007)

Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8
por: Ganguly, Dipyaman, et al.
Publicado: (2009)

Priming Dendritic Cells for Th2 Polarization: Lessons Learned from Helminths and Implications for Metabolic Disorders
por: Hussaarts, Leonie, et al.
Publicado: (2014)

Cd8(+) but Not Cd8(−) Dendritic Cells Cross-Prime Cytotoxic T Cells in Vivo
por: den Haan, Joke M.M., et al.
Publicado: (2000)

Cannot write session to /tmp/vufind_sessions/sess_g6v88u38iui9tfkacml4ukhp2d