Preparation, optimization, and in vitro simulated inhalation delivery of carvedilol nanoparticles loaded on a coarse carrier intended for pulmonary administration

Carvedilol (CAR) is a potent antihypertensive drug but has poor oral bioavailability (24%). A nanosuspension suitable for pulmonary delivery to enhance bioavailability and bypass first-pass metabolism of CAR could be advantageous. Accordingly, the aim of this work was to prepare CAR nanosuspensions...

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Detalles Bibliográficos
Autores principales: Abdelbary, Aly A, Al-mahallawi, Abdulaziz M, Abdelrahim, Mohamed E, Ali, Ahmed MA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608592/
https://www.ncbi.nlm.nih.gov/pubmed/26491298
http://dx.doi.org/10.2147/IJN.S91631

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