Cargando…

Reversible Ceftriaxone-Induced Pseudolithiasis in an Adult Patient with Maintenance Hemodialysis

Ceftriaxone (CTRX) is a third-generation cephalosporin widely used for the treatment of bacterial infections in patients with renal disease because of its excretion by both renal and hepatic mechanisms. Biliary pseudolithiasis is a known CTRX-associated complication; however, there have been no stud...

Descripción completa

Detalles Bibliográficos
Autores principales: Shima, Aya, Suehiro, Takaichi, Takii, Misaki, Soeda, Hiroyasu, Hirakawa, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608644/
https://www.ncbi.nlm.nih.gov/pubmed/26558252
http://dx.doi.org/10.1159/000440680
_version_ 1782395690289201152
author Shima, Aya
Suehiro, Takaichi
Takii, Misaki
Soeda, Hiroyasu
Hirakawa, Makoto
author_facet Shima, Aya
Suehiro, Takaichi
Takii, Misaki
Soeda, Hiroyasu
Hirakawa, Makoto
author_sort Shima, Aya
collection PubMed
description Ceftriaxone (CTRX) is a third-generation cephalosporin widely used for the treatment of bacterial infections in patients with renal disease because of its excretion by both renal and hepatic mechanisms. Biliary pseudolithiasis is a known CTRX-associated complication; however, there have been no studies of this adverse event in adult patients receiving maintenance hemodialysis. Here we report the case of a 79-year-old Japanese woman with end-stage renal disease (ESRD) receiving maintenance hemodialysis who developed CTRX-induced pseudolithiasis. The patient received CTRX for bronchial pneumonia. Fifteen days following CTRX initiation, the patient presented with stomachache. Because of the presence of one gallstone and increased gallbladder wall thickness on computed tomography scans, not detected at the onset of pneumonia, the patient was diagnosed with CTRX-induced gallbladder pseudolithiasis. CTRX was discontinued immediately. At 48 days following CTRX withdrawal, the gallstone and thickening of the gallbladder wall had completely resolved. ESRD may be a risk factor for CTRX-induced pseudolithiasis as hepatic excretion of CTRX is the predominant clearance mechanism in patients with ESRD. More attention should be paid to CTRX-induced pseudolithiasis following the use of CTRX in ESRD patients.
format Online
Article
Text
id pubmed-4608644
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher S. Karger AG
record_format MEDLINE/PubMed
spelling pubmed-46086442015-11-10 Reversible Ceftriaxone-Induced Pseudolithiasis in an Adult Patient with Maintenance Hemodialysis Shima, Aya Suehiro, Takaichi Takii, Misaki Soeda, Hiroyasu Hirakawa, Makoto Case Rep Nephrol Dial Published online: September, 2015 Ceftriaxone (CTRX) is a third-generation cephalosporin widely used for the treatment of bacterial infections in patients with renal disease because of its excretion by both renal and hepatic mechanisms. Biliary pseudolithiasis is a known CTRX-associated complication; however, there have been no studies of this adverse event in adult patients receiving maintenance hemodialysis. Here we report the case of a 79-year-old Japanese woman with end-stage renal disease (ESRD) receiving maintenance hemodialysis who developed CTRX-induced pseudolithiasis. The patient received CTRX for bronchial pneumonia. Fifteen days following CTRX initiation, the patient presented with stomachache. Because of the presence of one gallstone and increased gallbladder wall thickness on computed tomography scans, not detected at the onset of pneumonia, the patient was diagnosed with CTRX-induced gallbladder pseudolithiasis. CTRX was discontinued immediately. At 48 days following CTRX withdrawal, the gallstone and thickening of the gallbladder wall had completely resolved. ESRD may be a risk factor for CTRX-induced pseudolithiasis as hepatic excretion of CTRX is the predominant clearance mechanism in patients with ESRD. More attention should be paid to CTRX-induced pseudolithiasis following the use of CTRX in ESRD patients. S. Karger AG 2015-09-18 /pmc/articles/PMC4608644/ /pubmed/26558252 http://dx.doi.org/10.1159/000440680 Text en Copyright © 2015 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
spellingShingle Published online: September, 2015
Shima, Aya
Suehiro, Takaichi
Takii, Misaki
Soeda, Hiroyasu
Hirakawa, Makoto
Reversible Ceftriaxone-Induced Pseudolithiasis in an Adult Patient with Maintenance Hemodialysis
title Reversible Ceftriaxone-Induced Pseudolithiasis in an Adult Patient with Maintenance Hemodialysis
title_full Reversible Ceftriaxone-Induced Pseudolithiasis in an Adult Patient with Maintenance Hemodialysis
title_fullStr Reversible Ceftriaxone-Induced Pseudolithiasis in an Adult Patient with Maintenance Hemodialysis
title_full_unstemmed Reversible Ceftriaxone-Induced Pseudolithiasis in an Adult Patient with Maintenance Hemodialysis
title_short Reversible Ceftriaxone-Induced Pseudolithiasis in an Adult Patient with Maintenance Hemodialysis
title_sort reversible ceftriaxone-induced pseudolithiasis in an adult patient with maintenance hemodialysis
topic Published online: September, 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608644/
https://www.ncbi.nlm.nih.gov/pubmed/26558252
http://dx.doi.org/10.1159/000440680
work_keys_str_mv AT shimaaya reversibleceftriaxoneinducedpseudolithiasisinanadultpatientwithmaintenancehemodialysis
AT suehirotakaichi reversibleceftriaxoneinducedpseudolithiasisinanadultpatientwithmaintenancehemodialysis
AT takiimisaki reversibleceftriaxoneinducedpseudolithiasisinanadultpatientwithmaintenancehemodialysis
AT soedahiroyasu reversibleceftriaxoneinducedpseudolithiasisinanadultpatientwithmaintenancehemodialysis
AT hirakawamakoto reversibleceftriaxoneinducedpseudolithiasisinanadultpatientwithmaintenancehemodialysis