The Structural Basis for Activation and Inhibition of ZAP-70 Kinase Domain

ZAP–70 (Zeta-chain-associated protein kinase 70) is a tyrosine kinase that interacts directly with the activated T-cell receptor to transduce downstream signals, and is hence a major player in the regulation of the adaptive immune response. Dysfunction of ZAP–70 causes selective T cell deficiency th...

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Detalles Bibliográficos
Autores principales: Huber, Roland G., Fan, Hao, Bond, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608720/
https://www.ncbi.nlm.nih.gov/pubmed/26473606
http://dx.doi.org/10.1371/journal.pcbi.1004560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608720/
https://www.ncbi.nlm.nih.gov/pubmed/26473606
http://dx.doi.org/10.1371/journal.pcbi.1004560

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