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The Structural Basis for Activation and Inhibition of ZAP-70 Kinase Domain
ZAP–70 (Zeta-chain-associated protein kinase 70) is a tyrosine kinase that interacts directly with the activated T-cell receptor to transduce downstream signals, and is hence a major player in the regulation of the adaptive immune response. Dysfunction of ZAP–70 causes selective T cell deficiency th...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608720/ https://www.ncbi.nlm.nih.gov/pubmed/26473606 http://dx.doi.org/10.1371/journal.pcbi.1004560 |