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Shigella Effector OspB Activates mTORC1 in a Manner That Depends on IQGAP1 and Promotes Cell Proliferation

The intracellular bacterial pathogen Shigella infects and spreads through the human intestinal epithelium. Effector proteins delivered by Shigella into cells promote infection by modulating diverse host functions. We demonstrate that the effector protein OspB interacts directly with the scaffolding...

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Detalles Bibliográficos
Autores principales:	Lu, Richard, Herrera, Bobby Brooke, Eshleman, Heather D., Fu, Yang, Bloom, Alexander, Li, Zhigang, Sacks, David B., Goldberg, Marcia B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608727/ https://www.ncbi.nlm.nih.gov/pubmed/26473364 http://dx.doi.org/10.1371/journal.ppat.1005200

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