Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain

Dyshomeostasis of both ceramides and sphingosine-1-phosphate (S1P) in the brain has been implicated in aging-associated neurodegenerative disorders in humans. However, mechanisms that maintain the homeostasis of these bioactive sphingolipids in the brain remain unclear. Mouse alkaline ceramidase 3 (...

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Detalles Bibliográficos
Autores principales: Wang, Kai, Xu, Ruijuan, Schrandt, Jennifer, Shah, Prithvi, Gong, Yong Z., Preston, Chet, Wang, Louis, Yi, Jae Kyo, Lin, Chih-Li, Sun, Wei, Spyropoulos, Demetri D., Rhee, Soyoung, Li, Mingsong, Zhou, Jie, Ge, Shaoyu, Zhang, Guofeng, Snider, Ashley J., Hannun, Yusuf A., Obeid, Lina M., Mao, Cungui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608763/
https://www.ncbi.nlm.nih.gov/pubmed/26474409
http://dx.doi.org/10.1371/journal.pgen.1005591

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