Elisidepsin Interacts Directly with Glycosylceramides in the Plasma Membrane of Tumor Cells to Induce Necrotic Cell Death

Plasma membrane integrity is essential for cell life. Any major break on it immediately induces the death of the affected cell. Different molecules were described as disrupting this cell structure and thus showing antitumor activity. We have previously defined that elisidepsin (Irvalec(®), PM02734)...

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Detalles Bibliográficos
Autores principales: Molina-Guijarro, José Manuel, García, Carolina, Macías, Álvaro, García-Fernández, Luis Francisco, Moreno, Cristina, Reyes, Fernando, Martínez-Leal, Juan Fernando, Fernández, Rogelio, Martínez, Valentín, Valenzuela, Carmen, Lillo, M. Pilar, Galmarini, Carlos M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608773/
https://www.ncbi.nlm.nih.gov/pubmed/26474061
http://dx.doi.org/10.1371/journal.pone.0140782

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