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Relationship between Brain Age-Related Reduction in Gray Matter and Educational Attainment

Inter-subject variability in age-related brain changes may relate to educational attainment, as suggested by cognitive reserve theories. This voxel-based morphometry study investigated the impact of very low educational level on the relationship between regional gray matter (rGM) volumes and age in...

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Autores principales: Rzezak, Patricia, Squarzoni, Paula, Duran, Fabio L., de Toledo Ferraz Alves, Tania, Tamashiro-Duran, Jaqueline, Bottino, Cassio M., Ribeiz, Salma, Lotufo, Paulo A., Menezes, Paulo R., Scazufca, Marcia, Busatto, Geraldo F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608774/
https://www.ncbi.nlm.nih.gov/pubmed/26474472
http://dx.doi.org/10.1371/journal.pone.0140945
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author Rzezak, Patricia
Squarzoni, Paula
Duran, Fabio L.
de Toledo Ferraz Alves, Tania
Tamashiro-Duran, Jaqueline
Bottino, Cassio M.
Ribeiz, Salma
Lotufo, Paulo A.
Menezes, Paulo R.
Scazufca, Marcia
Busatto, Geraldo F.
author_facet Rzezak, Patricia
Squarzoni, Paula
Duran, Fabio L.
de Toledo Ferraz Alves, Tania
Tamashiro-Duran, Jaqueline
Bottino, Cassio M.
Ribeiz, Salma
Lotufo, Paulo A.
Menezes, Paulo R.
Scazufca, Marcia
Busatto, Geraldo F.
author_sort Rzezak, Patricia
collection PubMed
description Inter-subject variability in age-related brain changes may relate to educational attainment, as suggested by cognitive reserve theories. This voxel-based morphometry study investigated the impact of very low educational level on the relationship between regional gray matter (rGM) volumes and age in healthy elders. Magnetic resonance imaging data were acquired in elders with low educational attainment (less than 4 years) (n = 122) and high educational level (n = 66), pulling together individuals examined using either of three MRI scanners/acquisition protocols. Voxelwise group comparisons showed no rGM differences (p<0.05, family-wise error corrected for multiple comparisons). When within-group voxelwise patterns of linear correlation were compared between high and low education groups, there was one cluster of greater rGM loss with aging in low versus high education elders in the left anterior cingulate cortex (p<0.05, FWE-corrected), as well as a trend in the left dorsomedial prefrontal cortex (p<0.10). These results provide preliminary indication that education might exert subtle protective effects against age-related brain changes in healthy subjects. The anterior cingulate cortex, critical to inhibitory control processes, may be particularly sensitive to such effects, possibly given its involvement in cognitive stimulating activities at school or later throughout life.
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spelling pubmed-46087742015-10-29 Relationship between Brain Age-Related Reduction in Gray Matter and Educational Attainment Rzezak, Patricia Squarzoni, Paula Duran, Fabio L. de Toledo Ferraz Alves, Tania Tamashiro-Duran, Jaqueline Bottino, Cassio M. Ribeiz, Salma Lotufo, Paulo A. Menezes, Paulo R. Scazufca, Marcia Busatto, Geraldo F. PLoS One Research Article Inter-subject variability in age-related brain changes may relate to educational attainment, as suggested by cognitive reserve theories. This voxel-based morphometry study investigated the impact of very low educational level on the relationship between regional gray matter (rGM) volumes and age in healthy elders. Magnetic resonance imaging data were acquired in elders with low educational attainment (less than 4 years) (n = 122) and high educational level (n = 66), pulling together individuals examined using either of three MRI scanners/acquisition protocols. Voxelwise group comparisons showed no rGM differences (p<0.05, family-wise error corrected for multiple comparisons). When within-group voxelwise patterns of linear correlation were compared between high and low education groups, there was one cluster of greater rGM loss with aging in low versus high education elders in the left anterior cingulate cortex (p<0.05, FWE-corrected), as well as a trend in the left dorsomedial prefrontal cortex (p<0.10). These results provide preliminary indication that education might exert subtle protective effects against age-related brain changes in healthy subjects. The anterior cingulate cortex, critical to inhibitory control processes, may be particularly sensitive to such effects, possibly given its involvement in cognitive stimulating activities at school or later throughout life. Public Library of Science 2015-10-16 /pmc/articles/PMC4608774/ /pubmed/26474472 http://dx.doi.org/10.1371/journal.pone.0140945 Text en © 2015 Rzezak et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Rzezak, Patricia
Squarzoni, Paula
Duran, Fabio L.
de Toledo Ferraz Alves, Tania
Tamashiro-Duran, Jaqueline
Bottino, Cassio M.
Ribeiz, Salma
Lotufo, Paulo A.
Menezes, Paulo R.
Scazufca, Marcia
Busatto, Geraldo F.
Relationship between Brain Age-Related Reduction in Gray Matter and Educational Attainment
title Relationship between Brain Age-Related Reduction in Gray Matter and Educational Attainment
title_full Relationship between Brain Age-Related Reduction in Gray Matter and Educational Attainment
title_fullStr Relationship between Brain Age-Related Reduction in Gray Matter and Educational Attainment
title_full_unstemmed Relationship between Brain Age-Related Reduction in Gray Matter and Educational Attainment
title_short Relationship between Brain Age-Related Reduction in Gray Matter and Educational Attainment
title_sort relationship between brain age-related reduction in gray matter and educational attainment
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608774/
https://www.ncbi.nlm.nih.gov/pubmed/26474472
http://dx.doi.org/10.1371/journal.pone.0140945
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