Waterborne Risperidone Decreases Stress Response in Zebrafish

The presence of drugs and their metabolites in surface waters and municipal effluents has been reported in several studies, but its impacts on aquatic organisms are not yet well understood. This study investigated the effects of acute exposure to the antipsychotic risperidone on the stress and behav...

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Autores principales: Idalencio, Renan, Kalichak, Fabiana, Rosa, João Gabriel Santos, de Oliveira, Tiago Acosta, Koakoski, Gessi, Gusso, Darlan, de Abreu, Murilo Sander, Giacomini, Ana Cristina Varrone, Barcellos, Heloísa Helena de Alcântara, Piato, Angelo L., Barcellos, Leonardo José Gil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608780/
https://www.ncbi.nlm.nih.gov/pubmed/26473477
http://dx.doi.org/10.1371/journal.pone.0140800
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author Idalencio, Renan
Kalichak, Fabiana
Rosa, João Gabriel Santos
de Oliveira, Tiago Acosta
Koakoski, Gessi
Gusso, Darlan
de Abreu, Murilo Sander
Giacomini, Ana Cristina Varrone
Barcellos, Heloísa Helena de Alcântara
Piato, Angelo L.
Barcellos, Leonardo José Gil
author_facet Idalencio, Renan
Kalichak, Fabiana
Rosa, João Gabriel Santos
de Oliveira, Tiago Acosta
Koakoski, Gessi
Gusso, Darlan
de Abreu, Murilo Sander
Giacomini, Ana Cristina Varrone
Barcellos, Heloísa Helena de Alcântara
Piato, Angelo L.
Barcellos, Leonardo José Gil
author_sort Idalencio, Renan
collection PubMed
description The presence of drugs and their metabolites in surface waters and municipal effluents has been reported in several studies, but its impacts on aquatic organisms are not yet well understood. This study investigated the effects of acute exposure to the antipsychotic risperidone on the stress and behavioral responses in zebrafish. It became clear that intermediate concentration of risperidone inhibited the hypothalamic-pituitary-interrenal axis and displayed anxiolytic-like effects in zebrafish. The data presented here suggest that the presence of this antipsychotic in aquatic environments can alter neuroendocrine and behavior profiles in zebrafish.
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spelling pubmed-46087802015-10-29 Waterborne Risperidone Decreases Stress Response in Zebrafish Idalencio, Renan Kalichak, Fabiana Rosa, João Gabriel Santos de Oliveira, Tiago Acosta Koakoski, Gessi Gusso, Darlan de Abreu, Murilo Sander Giacomini, Ana Cristina Varrone Barcellos, Heloísa Helena de Alcântara Piato, Angelo L. Barcellos, Leonardo José Gil PLoS One Research Article The presence of drugs and their metabolites in surface waters and municipal effluents has been reported in several studies, but its impacts on aquatic organisms are not yet well understood. This study investigated the effects of acute exposure to the antipsychotic risperidone on the stress and behavioral responses in zebrafish. It became clear that intermediate concentration of risperidone inhibited the hypothalamic-pituitary-interrenal axis and displayed anxiolytic-like effects in zebrafish. The data presented here suggest that the presence of this antipsychotic in aquatic environments can alter neuroendocrine and behavior profiles in zebrafish. Public Library of Science 2015-10-16 /pmc/articles/PMC4608780/ /pubmed/26473477 http://dx.doi.org/10.1371/journal.pone.0140800 Text en © 2015 Idalencio et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Idalencio, Renan
Kalichak, Fabiana
Rosa, João Gabriel Santos
de Oliveira, Tiago Acosta
Koakoski, Gessi
Gusso, Darlan
de Abreu, Murilo Sander
Giacomini, Ana Cristina Varrone
Barcellos, Heloísa Helena de Alcântara
Piato, Angelo L.
Barcellos, Leonardo José Gil
Waterborne Risperidone Decreases Stress Response in Zebrafish
title Waterborne Risperidone Decreases Stress Response in Zebrafish
title_full Waterborne Risperidone Decreases Stress Response in Zebrafish
title_fullStr Waterborne Risperidone Decreases Stress Response in Zebrafish
title_full_unstemmed Waterborne Risperidone Decreases Stress Response in Zebrafish
title_short Waterborne Risperidone Decreases Stress Response in Zebrafish
title_sort waterborne risperidone decreases stress response in zebrafish
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608780/
https://www.ncbi.nlm.nih.gov/pubmed/26473477
http://dx.doi.org/10.1371/journal.pone.0140800
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