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Acidosis-Induced Dysfunction of Cortical GABAergic Neurons through Astrocyte-Related Excitotoxicity

BACKGROUND: Acidosis impairs cognitions and behaviors presumably by acidification-induced changes in neuronal metabolism. Cortical GABAergic neurons are vulnerable to pathological factors and their injury leads to brain dysfunction. How acidosis induces GABAergic neuron injury remains elusive. As th...

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Detalles Bibliográficos
Autores principales: Huang, Li, Zhao, Shidi, Lu, Wei, Guan, Sudong, Zhu, Yan, Wang, Jin-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608795/
https://www.ncbi.nlm.nih.gov/pubmed/26474076
http://dx.doi.org/10.1371/journal.pone.0140324