Synthesis of New 4-Aminoquinolines and Evaluation of Their In Vitro Activity against Chloroquine-Sensitive and Chloroquine-Resistant Plasmodium falciparum

The efficacy of chloroquine, once the drug of choice in the fight against Plasmodium falciparum, is now severely limited due to widespread resistance. Amodiaquine is one of the most potent antimalarial 4-aminoquinolines known and remains effective against chloroquine-resistant parasites, but toxicit...

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Detalles Bibliográficos
Autores principales: Rajapakse, Chandima S. K., Lisai, Maryna, Deregnaucourt, Christiane, Sinou, Véronique, Latour, Christine, Roy, Dipankar, Schrével, Joseph, Sánchez-Delgado, Roberto A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608832/
https://www.ncbi.nlm.nih.gov/pubmed/26473363
http://dx.doi.org/10.1371/journal.pone.0140878

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