Recurrent hypersomnia: Report of medication-responsive cases

INTRODUCTION: Recurrent hypersomnia (RH) is a rare disorder without established treatment. METHODS: We report 2 RH medication-responsive cases with typical characteristics of Kleine–Levin syndrome (KLS). CASE-REPORTS: A 10 y.o. girl and a 14 y.o. boy presented with sudden sleepiness for 3–9 days (ev...

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Detalles Bibliográficos
Autores principales: Perin, Bruna V., Rodrigues, Iorrana, Giasson, Franciele T.B., Balen, Matheus, Posenato, Naiana, Forcelini, Cassiano M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608889/
https://www.ncbi.nlm.nih.gov/pubmed/26483951
http://dx.doi.org/10.1016/j.slsci.2015.06.003
Descripción
Sumario:INTRODUCTION: Recurrent hypersomnia (RH) is a rare disorder without established treatment. METHODS: We report 2 RH medication-responsive cases with typical characteristics of Kleine–Levin syndrome (KLS). CASE-REPORTS: A 10 y.o. girl and a 14 y.o. boy presented with sudden sleepiness for 3–9 days (every 2–3 weeks). Physical examination, brain images and blood tests were normal. Polysomnographic findings were heterogenous, including disrupted sleep architecture. MSLTs revealed 2–3 SOREMPs and short sleep latency. Carbamazepine rendered girl׳s sleep normalization, while risperidone normalized boy׳s sleep cycles. CONCLUSIONS: Facing the absence of clinical trials in RH, reports of responsive cases are the available therapeutic evidence.

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