Inherited human group IVA cytosolic phospholipase A(2) deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation

Eicosanoids are important vascular regulators, but the phospholipase A(2) (PLA(2)) isoforms supporting their production within the cardiovascular system are not fully understood. To address this, we have studied platelets, endothelial cells, and leukocytes from 2 siblings with a homozygous loss-of-f...

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Detalles Bibliográficos
Autores principales: Kirkby, Nicholas S., Reed, Daniel M., Edin, Matthew L., Rauzi, Francesca, Mataragka, Stefania, Vojnovic, Ivana, Bishop-Bailey, David, Milne, Ginger L., Longhurst, Hilary, Zeldin, Darryl C., Mitchell, Jane A., Warner, Timothy D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2016
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608906/
https://www.ncbi.nlm.nih.gov/pubmed/26183771
http://dx.doi.org/10.1096/fj.15-275065

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