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P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite

BACKGROUND: The NLR family, pyrin domain-containing 3 (NLRP3) inflammasome plays a key role in intracerebral hemorrhage (ICH)-induced inflammatory injury, and the purinergic 2X7 receptor (P2X7R) is upstream of NLRP3 activation. This study aimed to investigate how P2X7R functions in ICH-induced infla...

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Detalles Bibliográficos
Autores principales:	Feng, Liang, Chen, Yizhao, Ding, Rui, Fu, Zhenghao, Yang, Shuo, Deng, Xinqing, Zeng, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609067/ https://www.ncbi.nlm.nih.gov/pubmed/26475134 http://dx.doi.org/10.1186/s12974-015-0409-2

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