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Long-term prognosis after resection of cryptogenic hepatocellular carcinoma

BACKGROUND: We investigated the patterns and predictors of recurrence and survival in cryptogenic non-B, non-C, non-alcoholic hepatocellular carcinoma (CR-HCC). We compared the findings with those hepatitis virus B (B) and hepatitis virus C (C)-HCC. CR-HCC does not include HCC developed on NASH. MET...

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Autores principales: Ohkura, Yu, Sasaki, Kazunari, Matsuda, Masamichi, Hashimoto, Masaji, Watanabe, Goro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609070/
https://www.ncbi.nlm.nih.gov/pubmed/26475278
http://dx.doi.org/10.1186/s12893-015-0099-9
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author Ohkura, Yu
Sasaki, Kazunari
Matsuda, Masamichi
Hashimoto, Masaji
Watanabe, Goro
author_facet Ohkura, Yu
Sasaki, Kazunari
Matsuda, Masamichi
Hashimoto, Masaji
Watanabe, Goro
author_sort Ohkura, Yu
collection PubMed
description BACKGROUND: We investigated the patterns and predictors of recurrence and survival in cryptogenic non-B, non-C, non-alcoholic hepatocellular carcinoma (CR-HCC). We compared the findings with those hepatitis virus B (B) and hepatitis virus C (C)-HCC. CR-HCC does not include HCC developed on NASH. METHODS: From 1990 to 2011, of 676 patients who underwent primary curative liver resection as initial therapy for HCC at our institution, 167 had B-HCC, 401 had C-HCC, and 62 had CR-HCC. Differences between three groups were analyzed using the Chi-squared test. Cumulative overall survival (OS) and disease-free survival (DFS) were determined by the Kaplan-Meier method, prognostic factors involved in OS/DFS were evaluated by univariate analysis using the log-rank test, and stepwise Cox regression analysis. RESULTS: Liver function was better in CR-HCC than in B/C-HCC, and mean tumor size was larger in CR-HCC than in B/C-HCC. In CR-HCC, OS was equivalent to that of B/C-HCC, and DFS was equivalent to that of B-HCC. Both tumor-related factors and background liver function appeared to be prognostic factors for three groups. CONCLUSION: Our findings indicate that the probability of survival of advanced CR-HCC was not longer than that of B/C-HCC. Given our findings, a postoperative follow-up protocol for CR-HCC should be established alongside that for B/C-HCC.
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spelling pubmed-46090702015-10-18 Long-term prognosis after resection of cryptogenic hepatocellular carcinoma Ohkura, Yu Sasaki, Kazunari Matsuda, Masamichi Hashimoto, Masaji Watanabe, Goro BMC Surg Research Article BACKGROUND: We investigated the patterns and predictors of recurrence and survival in cryptogenic non-B, non-C, non-alcoholic hepatocellular carcinoma (CR-HCC). We compared the findings with those hepatitis virus B (B) and hepatitis virus C (C)-HCC. CR-HCC does not include HCC developed on NASH. METHODS: From 1990 to 2011, of 676 patients who underwent primary curative liver resection as initial therapy for HCC at our institution, 167 had B-HCC, 401 had C-HCC, and 62 had CR-HCC. Differences between three groups were analyzed using the Chi-squared test. Cumulative overall survival (OS) and disease-free survival (DFS) were determined by the Kaplan-Meier method, prognostic factors involved in OS/DFS were evaluated by univariate analysis using the log-rank test, and stepwise Cox regression analysis. RESULTS: Liver function was better in CR-HCC than in B/C-HCC, and mean tumor size was larger in CR-HCC than in B/C-HCC. In CR-HCC, OS was equivalent to that of B/C-HCC, and DFS was equivalent to that of B-HCC. Both tumor-related factors and background liver function appeared to be prognostic factors for three groups. CONCLUSION: Our findings indicate that the probability of survival of advanced CR-HCC was not longer than that of B/C-HCC. Given our findings, a postoperative follow-up protocol for CR-HCC should be established alongside that for B/C-HCC. BioMed Central 2015-10-17 /pmc/articles/PMC4609070/ /pubmed/26475278 http://dx.doi.org/10.1186/s12893-015-0099-9 Text en © Ohkura et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Ohkura, Yu
Sasaki, Kazunari
Matsuda, Masamichi
Hashimoto, Masaji
Watanabe, Goro
Long-term prognosis after resection of cryptogenic hepatocellular carcinoma
title Long-term prognosis after resection of cryptogenic hepatocellular carcinoma
title_full Long-term prognosis after resection of cryptogenic hepatocellular carcinoma
title_fullStr Long-term prognosis after resection of cryptogenic hepatocellular carcinoma
title_full_unstemmed Long-term prognosis after resection of cryptogenic hepatocellular carcinoma
title_short Long-term prognosis after resection of cryptogenic hepatocellular carcinoma
title_sort long-term prognosis after resection of cryptogenic hepatocellular carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609070/
https://www.ncbi.nlm.nih.gov/pubmed/26475278
http://dx.doi.org/10.1186/s12893-015-0099-9
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