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Pretreatment but not subsequent coincubation with midazolam reduces the cytotoxicity of temozolomide in neuroblastoma cells

BACKGROUND: Temozolomide (TMZ) induces a G2/M cell cycle arrest and is used for treatment of paediatric tumours, especially neuroblastomas. Patients treated with TMZ frequently receive midazolam for sedation prior to surgery and other interventions. Previous studies suggested both cytoprotective and...

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Detalles Bibliográficos
Autores principales:	Braun, Sebastian, Bauer, Inge, Pannen, Benedikt, Werdehausen, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609078/ https://www.ncbi.nlm.nih.gov/pubmed/26475338 http://dx.doi.org/10.1186/s12871-015-0135-4

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