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FcγRIIB mediates antigen-independent inhibition on human B lymphocytes through Btk and p38 MAPK
BACKGROUND: The inhibitory Fc receptor, FcγRIIB, has emerged as a key negative regulator of B cell activation and as such is predicted to play an essential role in controlling antibody-mediated autoimmune diseases in humans. Recent studies have shown that crosslinking the FcγRIIB independently of th...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609082/ https://www.ncbi.nlm.nih.gov/pubmed/26475492 http://dx.doi.org/10.1186/s12929-015-0200-9 |