Pressure Overload by Transverse Aortic Constriction Induces Maladaptive Hypertrophy in a Titin-Truncated Mouse Model

Mutations in the giant sarcomeric protein titin (TTN) are a major cause for inherited forms of dilated cardiomyopathy (DCM). We have previously developed a mouse model that imitates a TTN truncation mutation we found in a large pedigree with DCM. While heterozygous Ttn knock-in mice do not display s...

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Detalles Bibliográficos
Autores principales: Zhou, Qifeng, Kesteven, Scott, Wu, Jianxin, Aidery, Parwez, Gawaz, Meinrad, Gramlich, Michael, Feneley, Michael P., Harvey, Richard P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609346/
https://www.ncbi.nlm.nih.gov/pubmed/26504781
http://dx.doi.org/10.1155/2015/163564

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